Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In this study, the regulatory role and mechanisms of tantalum (Ta) particles in the bone tissue microenvironment are explored. Ta particle deposition occurs in both clinical samples and animal tissues following porous Ta implantation. Unlike titanium (Ti) particles promoting M1 macrophage (Mϕ) polarization, Ta particles regulating calcium signaling pathways and promoting M2 Mϕ polarization. Ta-induced M2 Mϕ enhances bone marrow-derived mesenchymal stem cells (BMSCs) proliferation, migration, and osteogenic differentiation through exosomes (Exo) by upregulating miR-378a-3p/miR-221-5p and downregulating miR-155-5p/miR-212-5p. Ta particles suppress the pro-inflammatory and bone resorption effects of Ti particles in vivo and in vitro. In a rat femoral condyle bone defect model, artificial bone loaded with Ta particles promotes endogenous Mϕ polarization toward M2 differentiation at the defect site, accelerating bone repair. In conclusion, Ta particles modulate Mϕ polarization toward M2 and influence BMSCs osteogenic capacity through Exo secreted by M2 Mϕ, providing insights for potential bone repair applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/adhm.202303814 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reactivity of δ-Functionalized Para-Quinone Methides in Nucleophilic Addition Reactions.
Chemistry
July 2025
Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, München, Germany.
The electrophilic reactivities of para-quinone methides (pQMs) with functional groups (FG) at the exocyclic polarized carbon-carbon double bond were determined by photometrically monitoring the kinetics of their reactions with carbanions in dimethyl sulfoxide (DMSO) at 20 °C. The experimental second-order rate constants k were evaluated by the Mayr-Patz equation, that is, the linear free energy relationship lg k = s(N + E), which was leveraged to determine the electrophilicity descriptors E of the pQMs. These electrophilicity parameters E were subsequently used to successfully predict the scope of the pQM reactions with C-, H-, N-, O-, and S-centered nucleophiles.
View Article and Find Full Text PDFMulti-responsive Pickering emulsions stabilized by amphiphilic cellulose nanocrystals for building smart release systems of hydrophobic drugs.
Carbohydr Polym
May 2025
College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, PR China.
In this study, cellulose nanocrystals (CNC) were first extracted from peanut shells. Then, the monomers DMAEMA and MAA were grafted on the surface of CNC using reversible addition-fragmentation chain transfer (RAFT) polymerization to prepare multi-stimuli responsive nanoparticles (CNC/PDM), and they were used to stabilize Pickering emulsions. The effects of such factors as pH, nanoparticle concentration, water-to-oil ratio, and oil polarity on the stability of Pickering emulsions were investigated in detail.
View Article and Find Full Text PDFBand Gap Tuning in Mercaptoacetic Acid Capped Mixed Halides Perovskites and Effect of Solvents on Their Fluorescence Dynamics: A Potential Sensor for Polarity.
J Fluoresc
January 2025
Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
From synthesis to application, there are always certain interactions between the polar solvents and perovskite nanocrystals (NCs). To explain the effect of solvent polarity especially on the photoluminescence (PL) properties of NCs is highly desirable, especially for sensing applications. Herein We have synthesized the methylammonium lead mixed halides (MAPbClBr, where n = 0, 0.
View Article and Find Full Text PDFTough and Stretchable Zwitterionic Eutectogels via Copolymerization-Induced Phase Separation in a Targeted Deep Eutectic Solvent.
Macromol Rapid Commun
February 2025
College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, P. R. China.
Deep eutectic solvent (DES)-based eutectogels show significant promise for flexible sensors due to their high ionic conductivity, non-volatility, biocompatibility, and cost-effectiveness. However, achieving tough and stretchable eutectogels is challenging, as the highly polar DES tends to screen noncovalent bonds, such as hydrogen and ionic bonds, between polymer chains, limiting their mechanical strength. In this work, this issue is addressed by leveraging the limited solubility of zwitterionic polymers in a specific DES to induce phase separation, promoting dipole-dipole interactions between polymer chains.
View Article and Find Full Text PDFSynthesis and Performance Evaluation of Multialkylated Aromatic Amide Oligomeric Surfactants as Corrosion Inhibitor/Drag Reducing Agents for Natural Gas Pipeline.
ACS Omega
October 2024
Sino Oil King Shine Chemical Co., Ltd, Langfang, Hebei 065000, PR China.
Article Synopsis
- - The study explores how different molecular structures of multialkylated aromatic amides (MAAs), used as drag reducing agents (DRAs) in natural gas pipelines, impact energy efficiency and corrosion inhibition.
- - Researchers synthesized MAAs with varying numbers of amide groups and dodecane chains, finding that the molecular structure significantly influences the agents' interfacial activity and film-forming properties on carbon steel surfaces.
- - Results showed that MAAs with more amide groups and dodecane chains led to thicker and smoother films, enhancing corrosion inhibition and drag reduction rates—specifically, MAA-3 exhibited the highest performance among the synthesized surfactants.