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http://dx.doi.org/10.1038/s41419-024-06517-9 | DOI Listing |
bioRxiv
August 2025
Department of Molecular, Cellular, and Biomedical Sciences; College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH 03824.
The primary cilia of pyramidal neurons in inside-out laminated regions orient predominantly toward the pial surface, reflecting reverse soma re-positioning during postnatal development. However, the mechanisms underlying the directional cilia orientation and reverse movement are unknown. Here we show that the primary cilia of pyramidal neurons are localized near the base of the apical dendrites and aligned on the nuclear side opposite to the axon initial segment.
View Article and Find Full Text PDFActa Neuropathol Commun
August 2025
NeuroGenCell, Inserm U 1127, CNRS UMR 7225, ICM, Institut du Cerveau, Sorbonne Université, Paris, France.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by an abnormal expansion of cytosine-adenine-guanosine (CAG) trinucleotidein the huntingtin gene. Mutant huntingtin (mHTT) expression in neurons and glial cells affects neuron and astrocyte functions and leads to the loss of medium spiny neurons of the striatum. Brain cholesterol pathway is severely affected by HTT mutation in neurons and astrocytes, contributing to HD pathogenesis.
View Article and Find Full Text PDFNature
August 2025
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Biomol Biomed
August 2025
Department of Neurosurgery, Tenth Affiliated Hospital, Southern Medical University, Dongguan, Guangdong, China.
Correction to: Glioblastoma induces CAF-like astrocyte activation via the AKT/mTOR-SERPINH1/COL5A1 axis. This corrigendum corrects the authors' affiliations to: Jingxian Zhang¹,², Yajia Chen¹,², and Hongwu Xu¹,². ¹Department of Neurosurgery, Tenth Affiliated Hospital, Southern Medical University, Dongguan, Guangdong, China.
View Article and Find Full Text PDFNeural Regen Res
August 2025
Department of Pharmaceutical Sciences, Università del Piemonte Orientale "Amedeo Avogadro", Novara, Italy.
Cell function has a tight relationship with cell architecture. Distribution of proteins to the correct compartment is one of the functions of the traffic pathway through the Golgi apparatus. The others are to ensure proper protein folding, the addition of post-translational modifications, and delivering to intracellular and extracellular destinations.
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