Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Functional remodeling and prolonged anti-inflammatory responses are both vital for repairing damage in the cardiovascular system. Although these aspects have each been studied extensively alone, attempts to fabricate scaffolds that combine these effects have seen limited success. In this study, we synthesized salvianic acid A (SA, danshensu) blocked biodegradable polyurethane (PCHU-D) and enclosed it within electrospun nanofibers to synthesize a durable immunomodulatory nanofiber niche (DINN), which provided sustained SA release during inflammation. Given its excellent processability, mechanical properties, and shape memory function, we developed two variants of the DINN as vascular scaffolds and heart patches. Both these variants exhibited outstanding therapeutic effects in experiments. The DINN was expertly designed such that it gradually decomposes along with SA release, substantially facilitating cellular infiltration and tissue remodeling. Therefore, the DINN effectively inhibited the migration and chemotaxis of inflammatory cells, while also increasing the expression of angiogenic genes. As a result, it promoted the recovery of myocardial function after myocardial infarction and induced rapid reendothelialization following arterial orthotopic transplantation repair. These excellent characteristics indicate that the DINN holds great potential as a multifunctional agent for repairing cardiovascular tissues.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsnano.3c09692 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rare melanoma subtypes, including acral, mucosal, and uveal melanomas, exhibit limited responses to immune checkpoint inhibitors (ICIs), yet the molecular mechanisms of immune resistance remain poorly defined. Here, we performed transcriptomic profiling of patient-derived xenografts (PDXs) and publicly available tumor datasets to systematically compare intratumoral gene expression across cutaneous and rare melanoma subtypes. We identified a convergent downregulation of innate immune pathogen sensing (IIPS) and type I interferon signaling pathways in rare melanomas compared to cutaneous, with lower expression also observed in anti-PD-1 non-responder tumors.
View Article and Find Full Text PDFActivated Dendritic Cell Membrane-Engineered Nanoformulation of Metallo-Immunomodulators as Lysosome-Targeted Adjuvants for Synergistic Cancer Immunotherapy.
Adv Healthc Mater
September 2025
Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, 999077, China.
Combination of chemotherapy and cancer immunotherapy has shown substantial clinical promise. However, the immunosuppressive tumor microenvironment (TME) poses a critical barrier to this combination therapy. Here, a tumor lysosome-targeted immunomodulatory strategy based on a biomimetic nanoadjuvant is presented, which effectively overcomes the immunosuppressive TME and demonstrates enhanced therapeutic efficacy when combined with chemotherapy.
View Article and Find Full Text PDFNext-generation immunotherapy in relapsed/refractory multiple myeloma: Strategies to achieve sustained MRD negativity.
Crit Rev Oncol Hematol
August 2025
Department of Rheumatology, Ganzhou People's Hospital, Ganzhou, Jiangxi 341000, China.
This study critically examines the evolving landscape of Multiple Myeloma (MM) treatment, spotlighting the shift towards immunotherapeutic strategies in combating this complex hematological malignancy. Despite the clinical challenges posed by MM, including its high relapse and progression rates, recent therapeutic innovations have ushered in a new era of treatment possibilities. The advent of proteasome inhibitors and immunomodulatory drugs, and more recently BCMA‑targeted immunotherapies such as CAR‑T cells and bispecific antibodies, has broadened therapeutic options in multiple myeloma.
View Article and Find Full Text PDFTargeting STAT3 pathway: A promising immunotherapeutic strategy for triple-negative breast cancer - Current status and future outlooks.
Eur J Pharmacol
August 2025
Molecular Medicine Research Center, Tabriz University of Medical Science, Tabriz, Iran. Electronic address:
Triple-negative breast cancer (TNBC) remains one of the most aggressive and therapeutically challenging subtypes of breast cancer, largely due to its lack of hormone receptors and (human epidermal growth factor receptor 2) HER2 expression. Recent advances have highlighted the signal transducer and activator of transcription 3 (STAT3) as a critical oncogenic driver in TNBC pathogenesis and immune evasion, making it a promising target for immunotherapeutic intervention. This review explores the current landscape of STAT3-targeted therapies, discussing the detailed examination of upstream, downstream, and direct inhibitors of STAT3 in cancer management, emphasizing their mechanisms of action and preclinical/clinical progress.
View Article and Find Full Text PDFCombined cryotherapy and photodynamic therapy for recurrent generalized giant plantar warts: A case report.
Photodiagnosis Photodyn Ther
August 2025
Department of dermatology, The No.988 Hospital of Joint Logistic Support Force, Zhengzhou city, Henan Province, 450000, China. Electronic address:
Background: Plantar warts, caused by human papillomavirus(HPV),often present therapeutic challenges due to high recurrence rates and deep tissue infiltration. Traditional modalities like cryotherapy, CO laser, and surgery show limited efficacy for large or recurrent lesions.
Objective: To evaluate the clinical efficacy of cryotherapy combined with photodynamic therapy (PDT) and immunomodulatory agents in treating refractory giant plantar warts.