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Background: Plantar warts, caused by human papillomavirus(HPV),often present therapeutic challenges due to high recurrence rates and deep tissue infiltration. Traditional modalities like cryotherapy, CO laser, and surgery show limited efficacy for large or recurrent lesions.

Objective: To evaluate the clinical efficacy of cryotherapy combined with photodynamic therapy (PDT) and immunomodulatory agents in treating refractory giant plantar warts.

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