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http://dx.doi.org/10.1161/CIRCULATIONAHA.123.067528 | DOI Listing |
[This corrects the article DOI: 10.1371/journal.pone.
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Radiation Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
While immunotherapy has demonstrated encouraging efficacy in locally advanced nasopharyngeal carcinoma (LANPC), the optimal combination modalities and treatment duration remain undetermined. In the present study, we developed a clinical trial protocol to evaluate shortened period of immunotherapy could enhance the efficacy of LANPC. This open-label, randomized, single-blind, multicenter phase II trial (Tori-013) investigates the efficacy and safety of toripalimab (anti-PD-1 monoclonal antibody) combined with induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) in patients with stage III/IVa nasopharyngeal carcinoma (NPC).
View Article and Find Full Text PDFTrials
September 2025
Department of Emergency Medicine, CHU Nantes, Nantes Université, Nantes, France.
Background: Prehospital airway management is a critical and high-risk procedure in emergency medicine. First-pass intubation success is essential to reduce complications such as hypoxemia, aspiration, and hemodynamic instability. Although the bougie is commonly used in inhospital settings for difficult intubations, its routine use in first-attempt prehospital intubation in patients without difficult airway predictors has not been evaluated in randomized controlled trials.
View Article and Find Full Text PDFDrug Discov Ther
August 2025
Department of Ultrasonic Diagnosis, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
The aim of this study was to compare postoperative complications and long-term clinical efficacy of electrospun composite biomaterial and porcine small intestine submucosa (SIS) patch in open inguinal herniorrhaphy. A prospective, randomized, single-blind, controlled, multicenter study was used to select 172 patients with inguinal hernia who met the inclusion criteria in 3 hospitals. All participants were randomly assigned (1:1) and treated by open inguinal herniorrhaphy.
View Article and Find Full Text PDFJMIR Mhealth Uhealth
August 2025
Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea, 82 2-3010-3990, 82 2-3010-6968.
Background: Pulmonary rehabilitation improves exercise capacity, dyspnea, quality of life, and survival in patients with chronic respiratory disease. However, center-based pulmonary rehabilitation programs remain unavailable in many health care facilities due to several barriers. To address this, we developed a smartphone app that enabled individuals to perform pulmonary rehabilitation at home.
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