Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Delivery of aerosols to the lung can treat various lung diseases. However, the conducting airways are coated by a protective mucus layer with complex properties that make this form of delivery difficult. Mucus is a non-Newtonian fluid and is cleared from the lungs over time by ciliated cells. Further, its gel-like structure hinders the diffusion of particles through it. Any aerosolized treatment of lung diseases must penetrate the mucosal barrier. Using computational fluid dynamics, a model of the airway mucus and periciliary layer was constructed to simulate the transport of impacted aerosol particles. The model predicts the dosage fraction of particles of a certain size that penetrate the mucus and reach the underlying tissue, as well as the distance downstream of the dosage site where tissue concentration is maximized. Reactions that may occur in the mucus are also considered, with simulated data for the interaction of a model virus and an antibody.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634618 | PMC |
| http://dx.doi.org/10.1016/j.compchemeng.2023.108458 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reconstruction of three-dimensional fractures in coal based on multidirection slicing and U-Net segmentation.
J Adv Res
September 2025
State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources, China University of Mining and Technology at Beijing, Beijing 100083, China. Electronic address:
Introduction: Accurate characterization of multi-size fractures in coal is crucial for estimating its transport properties. However, the extraction of narrow microfractures in 3D voxel-type CT images is difficult, which causes the loss of connectivity in the extracted fracture network and reduces the accuracy of the predicted transport properties.
Objectives: Improving the image quality and optimizing the segmentation process to deal with the inaccuracy of fracture extraction from coal CT images.
CFD Evaluation of Far-UVCand Air Cleaning Technologies in Classrooms without Mechanical Ventilation.
J Hazard Mater
September 2025
Architectural Engineering Department, Pennsylvania State University, University Park, PA, USA. Electronic address:
Far-UVC systems and air cleaners are effective strategies for controlling airborne pathogen transmission, particularly in densely occupied spaces with insufficient ventilation, such as school classrooms. This study evaluates the disinfection performance and ozone (O) formation of different far-UVC systems and air cleaners in a standard-sized classroom using computational fluid dynamics (CFD) simulation. Results show that ceiling-mounted far-UVC systems reduce airborne pathogen exposure by up to 30 % more than upper-room and wall-mounted configurations, based on intake fractions and room-average concentrations.
View Article and Find Full Text PDFHaemodynamic characteristics of thin-walled regions in intracranial aneurysms: intraoperative imaging and CFD analysis.
Acta Neurochir (Wien)
September 2025
Faculty of Medicine, The University of Queensland, Herston, QLD, 4006, Australia.
Background: Identifying haemodynamic factors associated with thin-walled regions (TWRs) of intracranial aneurysms is critical for improving pre-surgical rupture risk assessment. Intraoperatively, these regions are visually distinguished by a red, translucent appearance and are considered highly rupture prone. However, current imaging modalities lack the resolution to detect such vulnerable areas preoperatively.
View Article and Find Full Text PDFDistributed Response to Distributed Intervening: Making Sense of Public Digitalization Through Digital Support.
J Med Humanit
September 2025
Faculty of Humanities, Saxo Institute, Copenhagen Centre for Health Research in the Humanities, University of Copenhagen, Copenhagen, Denmark.
Communication and interaction with public authorities and healthcare professionals in Denmark primarily go through digital self-service platforms, requiring diverse skills and device access. In this article, we describe how senior citizens in Denmark handle and make sense of public digitalization through different forms of digital support. Through an ethnographic study of community-led initiatives of digital support, we highlight how senior citizens find socio-technical ways of managing digital obligations and argue that citizens' digital agency in day-to-day interactions with public digitalization relies heavily on distributed socio-material relations.
View Article and Find Full Text PDFEnhanced mixing and mass transfer of non-Newtonian fluids for DHA production via Schizochytrium sp. fermentation.
Bioresour Technol
September 2025
College of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China. Electronic address:
Docosahexaenoic acid (DHA) production via aerobic fermentation of Schizochytrium sp. is a green strategy, and the fermentation broth is a highly viscous, non-Newtonian fluid. In this study, the mixing and mass transfer of non-Newtonian fluids were enhanced using computational fluid dynamics combined with particle image velocimetry.
View Article and Find Full Text PDF