Action at a distance: The remarkable coupling of CO uptake to electron transfer in specialized cyanobacterial NDH-1 complexes.

Cyanobacteria achieve highly efficient photosynthesis using a CO-concentrating mechanism relying on specialized Type I (NDH-1) complexes. Among these, NDH-1 and NDH-1 catalyze redox-coupled hydration of CO to bicarbonate, supporting carbon fixation in carboxysomes. The mechanism of coupling electron transfer to CO-hydration by these variant NDH-1 complexes remains unknown.

Social Connections Over the Life Course: Appreciating Distinct Dimensions of Social Connections.

Despite growing attention to the social isolation crisis in the U.S., it remains unclear whether Americans experience a decline in social connection with age.

Determining the mechanisms that cause woody plants to moderate microclimate in grasslands.

Forests and grasslands experience shifts in woody plant cover creating a continuum of woody plants across space. Global change accelerates this, causing many ecosystems to experience the redistribution of woody plants. There is growing interest in understanding how these ecological changes influence ecosystem function including climate regulation.

Biddle Physical Ability Test (BPAT) Performance by Attempt in Southern California Structural Firefighter Candidates.

The Biddle Physical Ability Test (BPAT) is a job task simulation that must be completed in ≤9:34 min:s by structural firefighter candidates to be accepted to a fire training academy. This study investigated the influence of prior attempts on BPAT time. Retrospective analysis was conducted on 1435 male and 72 female candidates.

Analysis of TERT association with clinical outcome in meningiomas: a multi-institutional cohort study.

Background: TERT promoter mutation is a rare biomarker in meningiomas associated with aberrant TERT expression and reduced progression-free survival. Although high TERT expression is characteristic of tumours with TERT promoter mutations, it has also been observed in tumours with wildtype TERT promoters. This study aimed to investigate the prevalence and prognostic association of TERT expression in meningiomas.

APE1 active site residue Asn174 stabilizes the AP-site and is essential for catalysis.

Apurinic/Apyrimidinic (AP)-sites are common and highly mutagenic DNA lesions that can arise spontaneously or as intermediates during Base Excision Repair (BER). The enzyme apurinic/apyrimidinic endonuclease 1 (APE1) initiates repair of AP-sites by cleaving the DNA backbone at the AP-site via its endonuclease activity. Here, we investigated the functional role of the APE1 active site residue N174 that contacts the AP-site during catalysis.

Diagnosis and treatment of inguinal midline abdominal wall herniation of the urinary bladder in three domestic rabbits (Oryctolagus cuniculus).

Inguinal herniation of the urinary bladder through the inguinal rings of domestic rabbits (Oryctolagus cuniculus) has been well-described in veterinary literature due to the inguinal rings remaining open throughout the lifespan of adult males. Midline body wall herniation has also been described in several veterinary species due to a variety of etiologies, including trauma, incisional dehiscence, and congenital anomalies. This phenomenon has not previously been described in rabbits.

Sex based relative expression of estrogen receptors and tumor necrosis factor-alpha in liver affects hepatitis C virus viral pathogenesis.

Background: Hepatocellular carcinoma (HCC) is a global health concern, representing the second most common cause of malignancy-related mortality in the world. The primary cause of HCC in the United States is chronic infection with the hepatitis C virus (HCV). Clinical observations have established sex-based differences in HCV infection with the disease progressing more severely and more rapidly in males and postmenopausal females compared to premenopausal females, suggesting that estrogens and their receptors may play an important role in hepatic defenses and development of HCV-mediated HCC.

Barriers to HIV/STI Services and Service Access Preferences Among Rural Sexual Minority Men and Native American Men in Oklahoma.

HIV and STI incidence are disproportionately elevated among sexual minority men (SMM) and Native American (NA) men in rural Oklahoma. The present study is a formative assessment of the Ending the HIV Epidemic in Rural Oklahoma (e-HERO) project, which is part of the Ending the HIV Epidemic (EHE) initiative. EHE has an overarching goal of reducing incidence rates of HIV and STIs in rural Oklahoma.

Progenitor cells, microglia, and non-coding RNAs: Orchestrators of glioblastoma pathogenesis and therapeutic resistance.

Glioblastoma (GB) remains a major challenge owing to its extremely aggressive nature and resistance to conventional therapies. This review focuses on the intricate roles of progenitor cells, microglia, and non-coding RNAs (ncRNAs) in orchestrating GB pathogenesis and therapy resistance. Glioma stem cells (GSCs), derived from progenitor cells, are important drivers of tumor initiation and recurrence and exhibit remarkable plasticity and resistance to treatment.

Genomic and Morphological Evidence Support Contemporary Three-Way Interspecific Hybridization in Ranid Frogs.

Hybridization is increasingly understood as common throughout and beyond the speciation process, rather than an anomaly. Sympatric taxa are expected to exhibit strong reproductive isolation, and although hybridization may occur, it often results in inviable offspring. We investigated hybridization among three ranid frogs (, , and ) in eastern Oklahoma, where their distributions and breeding phenology overlap.

Consequences of Bilingual Language Co-Activation for Higher-Order Cognition.

Hearing a single word can initiate a sequence of activation that spreads from the representation of the word (e.g., "candy") to words that share auditory and visual form (e.

Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration.

Skeletal muscle is an important organ in the human body for maintaining overall strength and mobility. Skeletal muscle has the capability of self-regeneration, which can be achieved by utilizing specific energy pathways. Therefore, understanding the energy metabolism of skeletal muscle is essential to exploring its regenerative mechanisms.

What is the status of (Ixodidae)?

The original description of is predominantly based on morphological and ecological characteristics. It was postulated that is a cryptic species of the complex, mainly found in the Mediterranean region of Spain, Portugal, Morocco, Algeria, and Tunisia. Although definitive proof is lacking, genetic insights support that is a distinct species, but that the morphological characteristics, particularly from the adult stages, as well as molecular features, might not be distinctive enough for identification.

Social Connectedness and Neurodevelopmental Functioning in Youth: Insights from the ABCD Study.

Objectives: Neurodevelopmental disorders have significant public health impacts, and novel approaches to understanding these disorders are greatly needed. Social connectedness, including relationships with parents and peers as well as family and school environments, may serve as a protective factor for neurodivergent youth. Neural networks that support social processing could also influence outcomes for these individuals.

Trait mindfulness as a strategy to mitigate substance use among American Indian/Alaska Native adults.

American Indian/Alaska Native (AI/AN) Peoples have endured centuries of colonization, resulting in lasting mental health effects (). Historical trauma has been linked to PTSD symptoms (e.g.

Identification of Small Signaling Peptide Encoding Genes Modulated by Host and Nonhost Bacterial Pathogens in Arabidopsis.

Small signaling peptides (SSPs) play a crucial role in various plant biological processes. However, the involvement of SSPs in plant immunity, particularly during host and nonhost bacterial infection remains largely unexplored. We established a pipeline using transcriptomics and genetic experimental validation and identified 243 upregulated and 194 downregulated SSPs upon host and nonhost bacterial pathogen inoculation in Arabidopsis.

Photonic terahertz phased array via selective excitation of nonlinear Pancharatnam-Berry elements.

Phased arrays are crucial in various technologies, such as radar and wireless communications, due to their ability to precisely control and steer electromagnetic waves. This precise control improves signal processing and enhances imaging performance. However, extending phased arrays to the terahertz (THz) frequency range has proven challenging, especially for high-frequency operation, broadband performance, two-dimensional (2D) phase control with large antenna arrays, and flexible phase modulation.

Near and far correlates of centenarian wellbeing.

Background And Objectives: The current study's model, derived from The Developmental Model of Adaptation, investigated the associations of past influences, closeness to parents, and two assessments of current influences (religiosity and social support) on the wellbeing (depressive symptomatology and life satisfaction) of very old adults.

Research Design And Methods: Cross-sectional data came from a convenience sample of 154 cognitively intact, community-dwelling, Oklahoma centenarians. SPSS was employed to assess descriptive statistics and associations among all constructs; M was employed to test a mediational path model linking closeness to parents on life satisfaction and depressive symptomatology through religiosity and social support.

Flower age increases male but not female performance through resource availability in a floral oil-producing species.

The high costs of floral maintenance modulate floral longevity. In some species with massive flowering and long floral lifespan, floral longevity increases overall display by changing petal colour, which ultimately counterbalances costs of floral maintenance. However, the colour of petals remains unchanged throughout the floral lifespan in some species with long floral longevity, and the reproductive consequences of such combined traits remain elusive.

Enablers and Barriers to Implementing Early Childhood Development Assessment and Nutrition Interventions in Community Settings: Qualitative Case Study From Sidama Regional State, Ethiopia.

Despite improvements in children's nutritional status and a commitment to early childhood development (ECD) policy developments in Ethiopia, the risk of poor ECD outcomes remains alarming. This study aimed to identify enablers and barriers to the implementation of ECD assessment and provision of nutrition-focused interventions in community settings. A qualitative case study was employed in Hawassa city and Dore Bafano district of Sidama region from November 2023 to February 2024.

Early Identification of Individual Nursery Pigs at Risk of Requiring Health Treatment Using Machine Learning.

Infectious disease is a major concern in the swine industry, impacting production as well as animal welfare. In this research, a prediction model for early identification of late nursery pigs within a batch that are at higher risk of requiring health treatments in a dynamic disease environment was developed based on early daily data on feeding and drinking and body weight. For this purpose, a unique dataset was used consisting of 21 batches of up to 75 late nursery pigs that were entered into a natural polymicrobial disease challenge barn to develop and evaluate the prediction models.

Age-Varying Patterns of Total Cholesterol by Modifiable Lifestyle Factors Across Mid to Late Adulthood: Applying Time-Varying Effect Modeling.

Objectives: Total cholesterol is a risk factor for cardiovascular disease, yet little is known about how its age-related trajectory differs by lifestyle factors across adulthood.

Methods: We analyzed data from 8758 adults aged 40-80 years using NHANES from 2011 to 2020. Total cholesterol was measured via enzymatic analysis of serum samples.

Effects of acute sleep deprivation and extreme fatigue on cognitive performance and cardiac autonomic function during an expedition adventure race: a case report.

Four ultra-endurance athletes (3M/1F) navigated ~800 km via trekking, biking, and paddling using topographical maps and compass, sleeping ~6 h each. Mood, cognitive performance, and heart rate variability were measured at baseline (PRE), post-race (POST), and 18-h post-race (POST18). Decreased anxiety (ΔMdn = 6.