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As the global population grows, the demand for beef and dairy products is also increasing. The cattle industry is facing tremendous pressures and challenges. The expanding cattle industry has led to an increased risk of disease in cattle. These diseases not only cause economic losses but also pose threats to public health and safety. Hence, ensuring the health of cattle is crucial. Vaccination is one of the most economical and effective methods of preventing bovine infectious diseases. However, there are fewer comprehensive reviews of bovine vaccines available. In addition, the variable nature of bovine infectious diseases will result in weakened or even ineffective immune protection from existing vaccines. This shows that it is crucial to improve overall awareness of bovine vaccines. Adjuvants, which are crucial constituents of vaccines, have a significant role in enhancing vaccine response. This review aims to present the latest advances in bovine vaccines mainly including types of bovine vaccines, current status of development of commonly used vaccines, and vaccine adjuvants. In addition, this review highlights the main challenges and outstanding problems of bovine vaccines and adjuvants in the field of research and applications. This review provides a theoretical and practical basis for the eradication of global bovine infectious diseases.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598632 | PMC |
http://dx.doi.org/10.3389/fvets.2023.1243835 | DOI Listing |
Can Vet J
September 2025
Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Pollock, Campbell, Waldner); Faculty of Veterinary Medicine, University of Calgary, 11877 85 Street NW, Calgary, Alberta T3R 1J3 (Windey
Objective: Our objective was to estimate the seroprevalences of 6 serovars in beef calves at or near fall weaning and assess how concentrations of serovar antibody titers in weaning-age calves varied with herd vaccination programs.
Animals: Serum was collected from 1922 beef calves from 106 herds in the Canadian Cow-Calf Surveillance Network (C3SN).
Procedure: A microscopic agglutination test was used to measure antibody titers for serovars Bratislava, Canicola, Grippotyphosa, Hardjo, Icterohaemorrhagiae, and Pomona.
Appl Biosaf
August 2025
Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.
Background: Serum and other blood-derived products are widely used in biomedical and biopharmaceutical processes, especially for the production of vaccines or cell therapeutic applications. To ensure quality and safety, each serum lot undergoes testing for sterility to minimize the risk of disease transmission. A currently performed standard procedure is gamma-irradiation of serum for effectively killing pathogens.
View Article and Find Full Text PDFJ Vet Diagn Invest
September 2025
Biology Department; Faculty of Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Lumpy skin disease (LSD) is a viral disease that affects livestock and is caused by the lumpy skin disease virus (LSDV). An outbreak of LSD in any country can lead to acute economic damage for livestock owners. The significance of prompt and accurate diagnosis in managing this viral disease cannot be overstated.
View Article and Find Full Text PDFInfect Immun
September 2025
National Contagious Bovine Pleuropneumonia Reference Laboratory, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Contagious bovine pleuropneumonia (CBPP), caused by subsp. (Mmm), is a devastating cattle disease with high morbidity and mortality, threatening cattle productivity in Sub-Saharan Africa and potentially in parts of Asia. Cross-border livestock trade increases the risk of CBPP introduction or reintroduction.
View Article and Find Full Text PDFAntiviral Res
September 2025
State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730030, P.R. China; Yazhouwan National Laboratory, Sanya 572024, P. R. China. Electronic addres
Due to the lack of timely vaccine prevention and effective drug treatment, lumpy skin disease is increasingly becoming a global epidemic, including in China. There is an urgent need to explore the pathogenic mechanism of lumpy skin disease virus (LSDV) and develop practical therapeutic approaches. The present study provides concrete evidence for the simultaneous induction and activation of nuclear ATM-mediated double-strand break and ATR kinase-dependent single-strand break signaling cascades during LSDV replication in the cytoplasm.
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