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Nocardiosis is an infectious disease caused by that primarily affects immunocompromised hosts. is a common opportunistic pathogen that causes disease in humans, including pulmonary and extrapulmonary infection. spp. infection is uncommon, and infection with and is even rarer. A 59-year-old immunocompetent woman with risk factors for environmental exposure developed nocardiosis and presented to the hospital with a cough, shortness of breath, hemoptysis, and a back abscess. An enhanced computed tomography (CT) of the chest revealed partial destruction of the right lung, as well as consolidation of the right upper lobe. Rare pathogens and were detected by metagenomic next-generation sequencing (mNGS) from abscess on the back and lung puncture tissue, respectively. She was treated with a combination of antibiotics and was finally discharged with a good prognosis. In this case, we present a patient who was successfully diagnosed with and infection using mNGS. This importance of using mNGS in pathogen detection and the effective use of antibiotics in treating patients with long-term rare infections is highlighted in this report.
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http://dx.doi.org/10.3389/fcimb.2023.1229298 | DOI Listing |
Helicobacter
September 2025
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Several clinical studies have demonstrated that Helicobacter pylori (Hp) infection may exacerbate the progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD); however, the underlying mechanisms remain unclear. This study aims to investigate the characterization of the gastric microbiome and metabolome in relation to the progression of MASLD induced by Hp infection.
Methods: We established a high-fat diet (HFD) obese mouse model, both with and without Hp infection, to compare alterations in serum and liver metabolic phenotypes.
Neurol Med Chir (Tokyo)
September 2025
Department of Neurosurgery, Tokyo Medical University.
Adhesive materials are widely used in microvascular decompression for treating neurovascular compression syndromes. They play an important role in the critical step of vessel fixation. Recently, completely autologous fibrin glue produced solely from a patient's own plasma was developed.
View Article and Find Full Text PDFNeurochirurgie
September 2025
Neurosurgery Department, Pasteur 2 Hospital, University Hospital of Nice, France.
Background: Posterior lumbar fusion (PLF) has become one of the most common spinal surgery procedures. Early symptomatic loosening of the pedicle screw could be a critical complication, leading to pseudarthrosis. However, revision strategies for pedicle screw loosening are still under debate.
View Article and Find Full Text PDFInt J Infect Dis
September 2025
Servicio de Brucellosis, Hospital F. J. Muñiz, 1282 Buenos Aires, Argentina.
Objectives: Brucellosis remains a significant zoonotic disease in endemic regions, with relapse and focal complications posing significant clinical challenges. This study aimed to identify risk factors associated with brucellosis relapse and focal disease in North Khorasan, Iran, over a nine-year period.
Methods: A retrospective analysis was conducted on 2,568 confirmed brucellosis cases from 2015 to 2024, using data from multiple centers.
Injury
September 2025
Washington University School of Medicine, Department of Orthopaedic Surgery, St. Louis, MO, USA. Electronic address:
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for Type 2 diabetes and obesity due to their cardiometabolic benefits. However, their effects on fracture healing remain controversial. This study investigates perioperative GLP-1 RA use and outcomes following surgical treatment of lower extremity (LE) fractures.
View Article and Find Full Text PDF