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Graded exertion testing (GXT) is an important tool for concussion management, as it is used to personalize post-concussion exercise prescription and return athletes to sport. However, most GXT requires expensive equipment and in-person supervision. Our objective was to assess the safety and feasibility of the ntreal irtual xertion (MOVE) protocol, a no-equipment, virtually compatible GXT, in healthy children and children with subacute concussion. The MOVE protocol consists of seven stages of bodyweight and plyometric exercises performed for 60 sec each. Twenty healthy (i.e., non-concussed) children completed the MOVE protocol virtually over Zoom Enterprise. Next, 30 children with subacute concussion (median: 31.5 days post-injury) were randomized to the MOVE protocol or Buffalo Concussion Treadmill Test (BCTT), which increases the incline or speed of the treadmill every minute until maximum exertion. Out of an abundance of caution, all concussed participants completed the MOVE protocol in an in-person clinical space. However, the test evaluator was stationed in a different room within the clinic and administered the MOVE protocol using Zoom Enterprise software to mimic telehealth conditions. Safety and feasibility outcomes were recorded throughout GXT, including heart rate, rate of perceived exertion (RPE), and symptom outcomes. No adverse events were recorded, and all feasibility criteria were successfully met in healthy youth and youth with concussion. Among concussed youth, increases in heart rate (MOVE: 82.4 ± 17.9 bpm, BCTT: 72.1 ± 23.0 bpm; t = 1.36, = 0.18), RPE (MOVE: 5.87 ± 1.92, BCTT: 5.07 ± 2.34, t = 1.02, = 0.32), and overall symptom presentation were similar between the MOVE and BCTT protocols. The MOVE protocol is a safe and feasible GXT in healthy youth and youth with subacute concussion. Future studies should assess the fully virtual administration of the MOVE in children with concussion, MOVE protocol tolerability in children with acute concussion, and whether the MOVE protocol can be used to guide individualized exercise prescription.
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http://dx.doi.org/10.1089/neu.2022.0370 | DOI Listing |
Temperature (Austin)
April 2025
Faculty of Sport Sciences, University of Poitiers, Laboratory, Mobilité, Vieillissement, Exercice (MOVE)-UR 20296, Poitiers, France.
The optimal Whole-body cryostimulation (WBC) exposure duration to reach the target skin temperature may vary depending on individual factors such as age, sex, and body mass index (BMI). Maintaining skin temperatures below 13.6°C is necessary to trigger significant cold-induced analgesia.
View Article and Find Full Text PDFPhysiotherapy
June 2025
PenCRU (Peninsula Childhood Disability Research Unit), Department of Health & Community Sciences, University of Exeter Medical School, University of Exeter, St Luke's Campus EX1 2LU, UK. Electronic address:
Objectives: Children and young people with complex neurodisability (CYPCN) are at high risk of respiratory illness, frequent hospital admissions and premature death. This study aimed to test the acceptability and feasibility of Breathe-Easy, a novel night-time postural intervention to improve respiratory health in CYPCN.
Design: Case series design incorporating a pre-post interventional study and qualitative study.
Biol Psychiatry
September 2025
Department of Psychiatry, University of Iowa, Iowa City, IA 52242; Iowa Neurosciences Institute, University of Iowa, Iowa City, IA 52242; Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242. Electronic address:
Perinatal mood and anxiety disorders (PMADs) are a spectrum of mental health conditions that are the most common pregnancy-related complications in the United States. Despite great strides in developing appropriate pharmacological and psychological treatments, PMADs continue to lack biological measures for diagnosis and prediction. Such measures could be effectively utilized to subtype and mechanistically explore PMADs and appropriately leverage mental healthcare resources.
View Article and Find Full Text PDFEMBO Rep
September 2025
Institute of Endotypes in Oncology, Metabolism and Immunology "G. Salvatore"-Second Unit (IEOMI-SU), National Research Council of Italy (CNR), Via P. Castellino 111, Napoli, Italy.
The classical models of intra-Golgi transport envision a movement of cargoes from cis- to trans-Golgi, followed by their sorting at the trans-Golgi network (TGN). During this vectorial transport, the cargoes are processed by sequentially acting glycosylation enzymes. A number of studies challenged the vectorial transport model and proposed alternative transport routes bypassing either directional transport or the TGN.
View Article and Find Full Text PDFJ Pain Res
August 2025
College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Purpose: Acute lateral ankle sprain (ALAS) is a prevalent clinical sports injury disease, rapid relief of symptoms and return to normal functional activity are urgent needs of ALAS patients. The aim of this study is to observe the immediate therapeutic effect of acupuncture on ALAS patients in the short term and to evaluate the efficacy at different time points through a multidimensional assessment system, which is expected to provide a simple, rapid, safe and effective therapeutic option for ALAS patients.
Patients And Methods: This is a single-center, prospective, randomized clinical trial.