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Insecticides play a critical role in controlling the spread of insect-borne diseases and preserving crop health. These chemical substances are specifically formulated to kill or manage insect populations. Over the years, various types of insecticides have been developed, including organophosphates, carbamates, pyrethroids, and neonicotinoids, each with unique modes of action, physiological targets, and efficacy. Despite the advantages that insecticides offer, it is imperative to recognize the potential consequences on non-target species, the environment, and human health. It is therefore crucial to follow recommended label instructions and employ integrated pest management practices for the judicious use of insecticides. This review article provides an in-depth examination of the various types of insecticides, including their modes of action, physiological targets, environmental and human health impacts, and alternatives. The aim is to furnish a comprehensive overview of insecticides and to emphasize the significance of responsible and sustainable utilization.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144373 | PMC |
http://dx.doi.org/10.3390/molecules28083641 | DOI Listing |
Trends Microbiol
September 2025
New Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen 518000, China; Southwest United Graduate School,
Mosquito-borne viral diseases pose a growing global health threat, with over half of the world's population living in high-risk areas. In the absence of effective vaccines or antiviral therapies for most mosquito-borne viruses, vector control remains the primary strategy. However, traditional insecticides face rising resistance and ecological concerns.
View Article and Find Full Text PDFBiology (Basel)
August 2025
College of Animal Science and Technology, Yangzhou University, 88 South University Rd, Yangzhou 225009, China.
Honeybees () are indispensable pollinators vital to global biodiversity, ecosystem stability, and agricultural productivity, and they promote over 35% of food crops and 75% of flowering plants. Yet, they are in unprecedented decline, partly as a result of neonicotinoid pesticide use elsewhere. These effects on honey bee health are synthesized in this paper through molecular, physiological, and behavioral data showing that sublethal effects of neonicotinoids impair honey bee health.
View Article and Find Full Text PDFJ Agric Food Chem
September 2025
State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China.
Indole, as a unique natural scaffold structure, has attracted considerable attention in recent years in the discovery of agrochemicals. As a distinct molecular scaffold, indole offers multiple modifiable sites and is extensively used in the development of new pesticides, such as fungicides, insecticides, herbicides, and antibacterial agents. Additionally, some indole derivatives can interact with various biological targets, enabling effective control of pathogens, pests, and weeds.
View Article and Find Full Text PDFRSC Med Chem
August 2025
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed-to-be University V. L. Mehta Road, Vile Parle (West) Mumbai-400056 Maharashtra India
Malaria is one of the most prevalent infectious diseases in the world. Despite the implementation of malaria prophylaxis by the WHO, the mortality rate has been rising. Owing to the development of resistance to presently prescribed antimalarial medication regimes in humans and insecticides in malaria vectors, the prevention and treatment of these illnesses are severely hindered.
View Article and Find Full Text PDFFEBS J
September 2025
Maharshi Dayanand University, Rohtak, India.
Malaria is a severe disease that is transmitted by female Anopheles mosquitoes and caused by the Plasmodium parasite. Despite a decrease in mortality rate, it continues to pose significant challenges such as resistance to antimalarial drugs and insecticides, which necessitates the need for novel malaria control and elimination strategies. To identify new molecular targets for malaria control, there is a need to understand the molecular interaction between mosquitoes and parasites.
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