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Polyetheretherketone (PEEK) can potentially be used for bone repair because its elastic modulus is similar to that of human natural bone and good biocompatibility and chemical stability. However, its hydrophobicity and biological inertness limit its application in the biomedical field. Inspired by the composition, structure, and function of bone tissue, many strategies are proposed to change the structure and functionality of the PEEK surface. In this review, the applications of PEEK in bone repair and the optimization strategy for PEEK's biological activity are reviewed, which provides a direction for the development of multifunctional bone repair materials in the future.
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http://dx.doi.org/10.1002/mabi.202300032 | DOI Listing |
Wounds
August 2025
Faculty of Physical Therapy, Cairo University, Cairo, Giza, Egypt.
Background: Charcot foot is a debilitating complication of peripheral neuropathy and is primarily associated with diabetes, leading to structural damage, ulceration, and osteomyelitis. Pulsed electromagnetic field (PEMF) therapy is a promising treatment modality for wound healing and bone metabolism.
Objective: To evaluate the efficacy of PEMF therapy in promoting bone growth and ulcer healing in patients with Charcot foot ulcers.
Ultrasound Med Biol
September 2025
State Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, China. Electronic address:
Objective: Diabetic foot ulcer (DFU) is a common and serious complication of diabetes, often leading to infection, amputation and poor quality of life. Bone marrow mesenchymal stem cells (BMSCs) have shown promise in treating chronic wounds, but their therapeutic efficacy is limited due to poor survival and low regenerative activity. Low-intensity pulsed ultrasound (LIUS), a non-invasive physical modality, has been shown to enhance the biological behavior of BMSCs.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Henan Key Laboratory of Materials on Deep-Earth Engineering, School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo, China. Electronic address:
A novel biodegradable bone cement (PSM) was successfully developed through the modification of magnesium oxychloride cement (MOC) with pectin, specifically addressing the inherent limitation of poor water resistance in conventional MOC. Properties of PSM such as washout resistance, setting time, mechanical properties and degradation properties were investigated. Results showed that PSM with 1.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Rapid Manufacturing Engineering Center, School of Mechatronical Engineering and Automation, Shanghai University, Shanghai, 200444, China; National Demonstration Center for Experimental Engineering Training Education, Shanghai University, Shanghai, 200444, China; Shanghai Key Laboratory of Intelligen
Osteochondral defects caused by trauma, obesity, tumors, and degenerative osteoarthropathies severely impair patients' quality of life. Multilayer tissue engineering scaffolds offer promising strategies for osteochondral repair by enhancing structural biomimicry. In this study, a triple-layer GelMA-alginate-based osteochondral scaffold (TCOS) was fabricated using an enhanced multi-axis, multi-process, multi-material 3D bioprinting system (MAPM-BPS).
View Article and Find Full Text PDFPhytomedicine
August 2025
Zhejiang Provincial Chinese Medicine Hospital (First affiliated hospital of Zhejiang Chinese Medical University), Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, 310053, China; Department of Orthopedics, Affiliated Hospital of Jiangxi University of Chinese Medicine, Jiangxi Un
Background: Osteoporotic osteoarthritis (OPOA), a distinct subtype of osteoarthritis (OA), has imposed a significant health and economic burden worldwide. However, mechanistic studies and therapeutic strategies for this disease remain in the exploratory stage.
Purpose: This study aimed to investigate the specific molecular mechanisms by which osteoporosis (OP) exacerbates OA progression through accelerated subchondral bone (SB) sclerosis and the potential of Jiawei Yanghe Decoction (JWYHD) in treating OPOA.