Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Three new rearranged diterpenoids, strophioblachins A-C (-), eight new diterpenoids, strophioblachins D-K (-), and seven previously described diterpenoids (-) were purified from the aerial parts of Compounds and contain a rare 6/6/5/6 ring system, while has an uncommon tricyclo[4.4.0.0]tridecane-bridged unit, and their diterpenoid skeletons are being reported for the first time. Utilizing spectroscopic and HRESIMS data analysis, the structures of the new compounds (-) were established, and ECD and C NMR calculations were used to confirm the relative and absolute configurations of and . The absolute configurations of compounds , , and were established using single-crystal X-ray diffraction. The results of testing for anticardiac hypertrophic activity demonstrated that compounds and dose-dependently lowered the mRNA expression of and . Protein levels were confirmed by Western blotting, which also demonstrated that compounds and lowered the expression of the hypertrophic marker ANP. The cytotoxic activity against neonatal rat cardiomyocytes was assayed in vitro by the CCK-8 and ELISA methods, and the results showed that compounds and were only very weakly active in the range.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jnatprod.2c01115 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Interplay of downregulation and inflammatory dysregulation in hypertrophic cardiomyopathy pathogenesis.
Front Cardiovasc Med
June 2025
Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Background: Hypertrophic Cardiomyopathy (HCM) is an inherited heart disease and the pathogenesis of HCM involves genetic mutations, hemodynamic stress, and metabolic factors, with myocardial fibrosis playing a crucial role in severe clinical events. IL-33/ST2 signaling pathway known for its roles in immune response and tissue repair, participates in cardiac protection and anti-cardiac fibrosis in heart failure. The role of in HCM remains unclear, and IL-33/ST2 pathway and broader inflammatory responses may be critical in HCM.
View Article and Find Full Text PDFTriketone-acylphloroglucinol-monoterpenoid hybrids from Callistemon viminalis, a new structural template of anti-cardiac hypertrophy.
Bioorg Chem
July 2025
State Key Laboratory of Phytochemistry and Natural Medicines, and Yunnan Characteristic Plant Extraction Laboratory, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address:
Seven new β-triketone-acylphloroglucinol-monoterpenoid hybrids, namely callistevimones A-G (1-7), were isolated from Callistemon viminalis fruits. Their structures and absolute stereochemistry were accomplished through a comprehensive analytical method involving mass spectrometry, NMR, ECD calculation, QM-NMR calculation, and single-crystal X-ray crystallography. Compounds 1 and 2 are first examples of β-triketone-acylphloroglucinol-phellandrene with an enlarged-ring.
View Article and Find Full Text PDFIncidence and Impact of Myocarditis in Genetic Cardiomyopathies: Inflammation as a Potential Therapeutic Target.
Genes (Basel)
January 2025
Institute of Clinical Medicine, V.N. Vinogradov Faculty Therapeutic Clinic, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Background: Myocardial disease is an important component of the wide field of cardiovascular disease. However, the phenomenon of multiple myocardial diseases in a single patient remains understudied.
Aim: To investigate the prevalence and impact of myocarditis in patients with genetic cardiomyopathies and to evaluate the outcomes of myocarditis treatment in the context of cardiomyopathies.
Podocarpane and cleistanthane diterpenoids from Strophioblachia glandulosa: structural elucidation, anti-hypertrophy activity and network pharmacology.
Bioorg Chem
January 2025
Key Laboratory of Medicinal Chemistry for Natural Resource of ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, and School of Pharmacy, State Key Laboratory for Conservation
In the present investigation, fourteen unprecedented podocarpane diterpenoids strophiolosas A-J, L-N and P (1-10, 12-14, 16), two new cleistanthane derivatives strophiolosas Q-R (17-18), two new dibenzopyroan-ones and one new tetralone strophiolosas S-U (19-21), were isolated from the whole plant of Strophioblachia glandulosa. The structures were elucidated via various spectroscopic analysis, quantum chemistry calculations, and X-ray diffraction. Bioactivity test indicated that compounds 5 and 17 possessed promising anti-cardiac hypertrophy effect in vitro (IC values of 16.
View Article and Find Full Text PDFGQ262 Attenuates Pathological Cardiac Remodeling by Downregulating the Akt/mTOR Signaling Pathway.
Int J Mol Sci
September 2024
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
Cardiac remodeling, a critical process that can lead to heart failure, is primarily characterized by cardiac hypertrophy. Studies have shown that transgenic mice with Gαq receptor blockade exhibit reduced hypertrophy under induced pressure overload. GQ262, a novel Gαq/11 inhibitor, has demonstrated good biocompatibility and specific inhibitory effects on Gαq/11 compared to other inhibitors.
View Article and Find Full Text PDF