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Scleroderma is a group of autoimmune diseases that principally affects the skin, blood vessels, muscles, and viscera. One of the more well-known subgroups of scleroderma is the limited cutaneous form of the multisystem connective tissue disorder known as CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasis) syndrome. In this report, we present a case of a spontaneous colonic bowel perforation in a patient with incomplete features of CREST. Our patient underwent a complicated hospital course involving broad-spectrum antibiotic coverage, surgical hemicolectomy, and immunosuppressives. She was eventually discharged home with a return to functional baseline status after esophageal dysmotility confirmation via manometry. Physicians managing patients with scleroderma ensuing to an emergency department encounter must anticipate the multitude of complications that can occur, as was seen in our patient. The threshold for pursuing imaging and additional tests, in addition to admission, should be relatively low, given the extremely high rates of complications and mortality. Early multidisciplinary involvement with infectious disease, rheumatology, surgery, and other respective specialties is crucial for patient outcome optimization.
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http://dx.doi.org/10.2196/43295 | DOI Listing |
Microbiol Res
September 2025
Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China. Electronic address:
Intractable functional constipation (IFC), a severe form of chronic constipation characterized by slow transit and resistance to conventional treatments, posed a significant clinical challenge. Here, we identified Lactococcus formosensis (Lf), a Gram-positive bacterium prevalent in IFC patients, as a novel contributor to intestinal motility impairment. Clinically, IFC patients exhibited increased colonic mucosal colonization of Lf and significant myenteric neuronal loss and pyroptosis, particularly in excitatory choline acetyltransferase (ChAT) neurons, but not inhibitory neuronal nitric oxide synthase (nNOS) neurons.
View Article and Find Full Text PDFBackground: In the presence of a potent P2Yinhibitor such as prasugrel, the additional clinical antithrombotic benefit of aspirin is unclear. The feasibility of prasugrel monotherapy without aspirin after percutaneous coronary intervention (PCI) has been demonstrated in chronic coronary syndrome, but is yet to be assessed in patients with non-ST elevation acute coronary syndrome (NSTE-ACS) and low anatomical complexity.
Methods And Results: ASET-Japan is a single-arm study investigating the safety of prasugrel 12-month monotherapy with a locally approved dose (loading 20 mg; maintenance 3.
Front Cell Infect Microbiol
September 2025
Hunan Key Laboratory of Traditional Chinese Medicine Prescription and Syndromes Translational Medicine, Hunan University of Chinese Medicine, Changsha, China.
Introduction: Sishen Pill (SSP), a classic TCM formula, warms the kidney and spleen, astringes the intestine, and stops diarrhea. Emerging evidence suggests that diarrhea with KYDS is linked to gut microbiota imbalance and altered intestinal enzyme activities. At the same time, SSP has been shown to regulate gut microbiota, improve metabolism, and alleviate intestinal disorders.
View Article and Find Full Text PDFFood Funct
September 2025
Laboratory of Genetics, Wageningen University and Research, Wageningen, The Netherlands.
Traditional fermented foods (TFFs) spark debates about their potential health benefits as much is still unclear. Mostly conjectured as functional or living foods, TFFs are produced by live organisms through spontaneous or controlled fermentation processes. Here, we assessed the effect of exposure to Mabisi, a traditional Zambian fermented dairy food product, on the gut microbiota and production of short-chain fatty acids (SCFAs) in stool samples of consumers and non-consumers of Mabisi.
View Article and Find Full Text PDFCase Rep Gastroenterol
February 2025
Department of Gastroenterology, No. 971 Naval Hospital of Chinese PLA, Qingdao, China.
Introduction: Colonic pseudolipomatosis is a rare benign lesion with distinct endoscopic and histological features. The etiology and pathogenesis of colonic pseudolipomatosis have not been fully clarified and are still controversial to some extent. It is particularly noteworthy that this lesion must be differentiated from real pathological entities to avoid further unnecessary auxiliary examinations and overtreatments.
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