Gluten-free journeys: an evaluation of online travel health information for patients living with coeliac disease.

Coeliac disease is a widely prevalent chronic condition, which presents potential challenges during international travel. Our analysis of information provided by national coeliac disease organisations points to the need to make more comprehensive and standardised travel health advice available online to people living with coeliac disease.

Protocol for an umbrella review of the state-of-science on public and patient involvement in health and social care research with children, young people and families.

Background: Public and Patient Involvement (PPI) refers to the active collaboration of patients and the public in health and social care research decision-making, enhancing research success, cost-effectiveness, and impact. Children, young people, and their families bring unique lived experiences to PPI in research, relating to others with similar experiences, while factors like age, cognitive maturation, and developmental stage create differences between researchers and patients or the public. Collaboration with children, young people, and their families should be guided by specific project context and a strong evidence base.

Action design research to develop an interactive dashboard to visualise and compare patient data from Irish general practice (CARA).

Objective: A dashboard was developed with and for Irish general practitioners (GPs) to improve their understanding of practice data. The aim of this study was to design and develop interactive CARA dashboards to enable Irish GPs to visualise patient data and compare their data with other practices.

Design: An interpretivist qualitative approach was taken to create a deeper understanding of how GPs view and engage with data.

Case report: An endoscopic approach to the middle ear following significant penetrating trauma.

Introduction And Importance: While blunt trauma to the head is a well-recognized cause of middle ear injuries, penetrating traumas are far less common. Due to the close anatomical relations, the potential consequences of such injuries can be catastrophic.

Case Presentation: A man presented following a penetrating injury to the external auditory canal.

Iron Oxide Nanoparticle Uptake, Toxicity, and Steroidogenesis in Adrenocortical Carcinoma Cells Using a Multicellular in vitro Model.

Introduction: Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis, limited treatment options, and high recurrence rates. Surgery and mitotane-based chemotherapy remain the standard of care, and new treatment strategies are needed. Iron oxide nanoparticles (IONPs) offer promise as theranostic agents due to their modifiability for selective uptake and imaging.

Circumventing Radical Generation on Fe-V Atomic Pair Catalyst for Robust Oxygen Reduction and Zinc-Air Batteries.

Iron-nitrogen-carbon (Fe-N-C) catalysts are considered the most active platinum-free alternative for oxygen reduction reaction (ORR), yet the generated reactive oxygen species (ROS) from general mechanistic pathway rapidly impair the ORR activity and stability of Fe-N-C. Herein, we establish and report an ORR pathway-switching strategy to circumvent ROS generation and fundamentally improve the activity and stability of Fe-N-C via DFT guided catalyst design. The constructed Fe-V atomic pair catalyst (FeV-NC) with NFe-N-VN configuration enables side-on adsorption of O and subsequent direct-breaking of the O═O bond to form O*, thereby avoiding the formation of ROS radicals.

Aspirin-Free Prasugrel Monotherapy After Percutaneous Coronary Intervention in Patients With Non-ST Elevation Acute Coronary Syndrome.

Background: In the presence of a potent P2Yinhibitor such as prasugrel, the additional clinical antithrombotic benefit of aspirin is unclear. The feasibility of prasugrel monotherapy without aspirin after percutaneous coronary intervention (PCI) has been demonstrated in chronic coronary syndrome, but is yet to be assessed in patients with non-ST elevation acute coronary syndrome (NSTE-ACS) and low anatomical complexity.

Methods And Results: ASET-Japan is a single-arm study investigating the safety of prasugrel 12-month monotherapy with a locally approved dose (loading 20 mg; maintenance 3.

The use of virtual rehabilitation Augmented Reality (AR) exergames for patients with osteoporosis to improve balance, muscle strength and confidence: Study design for a clinical trial.

Osteoporosis is a major bone disease, affecting more than 200 million people globally. Physical exercise is a powerful non-pharmaceutical fracture prevention strategy for people with osteoporosis or those at risk of falls. However, the participation in and adherence to an exercise regimen by older adults is often low due to a lack of motivation, a fear of falling, safety and/or cost.

Organic ultraviolet filters in Irish sediments and biosolids.

This study provides baseline data on the concentrations of selected ultraviolet filters (UVFs) in 81 inland and transitional sediments as well as in 21 agricultural biosolid samples sourced from seven wastewater treatment plants (WWTP) across Ireland. Concentrations of five prominent UVFs were determined: 4-methylbenzylidene camphor (4-MBC); benzophenone-3 (BP-3); 2-ethylhexyl-4-methoxycinnamate (EHMC); homosalate (HMS); and Octocrylene (OC). Mean concentrations in sediments were as follows: OC (3.

A steep decline in diastolic blood pressure over early to mid-life is associated with tau-PET burden in dementia-free adults.

BackgroundThe relationship between blood pressure (BP) trajectories across early (∼40 years) into mid-life (∼55 years) and preclinical dementia has not previously been well studied using positron emission tomography (PET) imaging outcomes.ObjectiveTo examine the association between BP trajectories across early mid-life into mid mid-life and amyloid- and tau-PET burden in adults without clinical dementia.MethodsThis prospective cohort study included dementia-free Framingham Heart Study 3 generation participants with data on remote BP (2002-2005) and recent BP (2016-2019) who participated in C-Pittsburgh Compound-B (PiB)-PET and/or F-Flortaucipir (FTP)-PET scans between 2016 to 2022.

Collagen scaffold anisotropy and static tension maintain human tendon cell phenotype in culture.

Biophysical in nature signals, due to their simplicity in implementation, are at the forefront of research and innovation to control tendon cell function in vitro. In this work, we first assessed the influence of substrate rigidity and surface topography on human tendon cells using differentially crosslinked planar and grooved collagen scaffolds. We identified the 0.

Consistent asymmetry in DNA damage artefacts across target regions in exome sequencing data.

Oxidative damage can introduce G>T mutations upon DNA replication. When this damage occurs , sequenced DNA exhibits strand asymmetry, whereby sequence alignment yields G>T mismatches without corresponding C>A mismatches on the complementary strand at a given locus. Strand asymmetry is used to identify potential sequencing artefacts in somatic variant calls in cancer sequencing projects.

Impact of genotypes, environmental stresses, and genotype by environment interactions on growth and yield of quinoa at flowering stage.

Flowering is a critical growth stage of quinoa (Chenopodium quinoa Willd.), with a strong influence on growth and grain yield. To understand factors affecting such flowering stage effects, we measure the differential effects of genotype (G), environmental stress (E), and genotype by environment interaction (G × E) on quinoa growth and yield-related traits during the flowering stage.

A biphasic microstructural model of skeletal muscle to study structure-function mechanisms under multiaxial tensile and compressive conditions.

The passive material properties of skeletal muscle are key to proper force transmission, and changes to muscle microstructure can have deleterious effects on whole tissue function. However, to the best of the authors' knowledge, it is not currently possible to predict the passive material properties of skeletal muscle with microstructural measurements such as titin isoform type and/or extracellular matrix collagen content, type, or organization. The goals of this work were to 1) develop an experimental dataset at the tissue length scale of passive skeletal muscle under multiaxial loading conditions, 2) develop a biphasic microstructural model of skeletal muscle, and 3) calibrate, validate, and implement such a model.

Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes.

Background: Whether potent P2Y12 inhibitor monotherapy without aspirin initiated shortly after successful percutaneous coronary intervention (PCI) is effective and safe for patients with acute coronary syndromes is unclear.

Methods: We conducted a multicenter, open-label, randomized trial in Brazil involving patients with acute coronary syndromes who had undergone successful PCI. Patients were assigned in a 1:1 ratio within the first 4 days of hospitalization to stop treatment with aspirin and receive potent P2Y12 inhibitor monotherapy (ticagrelor or prasugrel) or to receive dual antiplatelet therapy (aspirin and a potent P2Y12 inhibitor) for 12 months.

Assessing the Potential of Caprine Collagen Type I in the Development of Medical Devices.

We isolated collagen I from caprine, porcine, and bovine skin and tendon tissues and assessed their purity and chemical properties. We fabricated non-cross-linked and cross-linked scaffolds from each collagen I preparation and assessed their physicochemical and biological properties. Purity and chemical analyses did not reveal any notable differences between the groups.

Effect of intra-articular adipose-derived mesenchymal stromal cell versus placebo injection on pain and function in patients with knee osteoarthritis: the ADIPOA2 phase 2b randomised clinical trial.

Objectives: This study aims to evaluate the efficacy of intra-articular autologous adipose-derived ex vivo expanded mesenchymal stromal cells (ADSC) on patient-reported outcome (pain and function) in symptomatic mild-to-moderate tibiofemoral knee osteoarthritis (OA).

Methods: Participants were randomised in a prospective, double-blind, controlled phase 2b study to receive 1 single intra-articular injection in 3 separate groups: ADSC low dose 2 × 10 cells; ADSC high dose 10 × 10 cells; or saline placebo. The primary outcome was the rate of OsteoArthritis Research Society International (OARSI)/Outcome MEasures in Rheumatology (OMERACT) 'strict responders' defined by improvements from baseline reported to 0 to 100 mm scale in Western Ontario and McMaster University Osteoarthritis index (WOMAC) pain or physical function subscores ≥50% with minimal absolute changes ≥20 mm at 6 months.

Effects of grassland community composition and digestate fertiliser on nitrous oxide emissions from soil.

The agriculture sector is under considerable pressure to reduce greenhouse gas (GHG) emissions. The use of grass from farmland as a feedstock for anaerobic digestion (AD) can contribute to the development of biomethane as a renewable energy. Digestate, a by-product of AD, can be recycled as a source of N fertilizer on grassland, but little is known about its nitrous oxide (NO) emissions (a potent greenhouse gas) following land-spreading.

The Impact of a Multidisciplinary Patient Education Program on Venous Leg Ulcer Healing: A Randomised Controlled Trial.

To evaluate the impact of a nurse-led, multidisciplinary education programme on wound healing, patient knowledge, and adherence to compression therapy, physical activity, and nutrition in individuals with venous leg ulcers (VLU). In this randomised controlled trial, 87 patients with VLU from three outpatient clinics in Western Switzerland were allocated to an intervention group (IG) receiving structured education plus standard care, or a control group (CG) receiving standard care alone. The 12-month intervention included in-person education, counselling, and follow-ups.