Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Fluorescence-guided phototherapy, including photodynamic and photothermal therapy, is considered an emerging noninvasive strategy for cancer treatments. Organic molecules are promising theranostic agents because of their facile construction, simple modification, and good biocompatibility. Organic systems that integrated multifunctionalities in a single component and achieved high efficiency in both imaging and therapies are rarely reported as the inherently competitive energy relaxation pathways are hard to modulate, and fluorescence quenching occurs upon molecular aggregation. Herein, a versatile theranostic platform with near-infrared emission, high fluorescence quantum yield, robust reactive oxygen species production, and excellent photothermal conversion efficiency was developed based on an aggregation-induced emission luminogen, namely, TPA-TBT. studies revealed that the TPA-TBT nanoaggregates exhibit outstanding photodynamic and photothermal therapy efficacy to ablate tumors inoculated in a mouse model. This work offers a design strategy to develop one-for-all cancer theranostic agents by modulating and utilizing the relaxation energy of excitons in full.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsnano.2c10661 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development of smartphone-based AIE fluorescence-quenching immunochromatographic sensors for the detection of illicit drugs in various complex sample matrices.
Anal Bioanal Chem
September 2025
GuangDong Engineering Technology Research Center of Antibody Drug and Immunoassay, Department of Biological Sciences and Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Illicit drug abuse poses a significant global threat to public health and social security, highlighting the urgent need for rapid, sensitive, and versatile detection technologies. To address the limitations of traditional chromatographic techniques-such as high costs and slow response times-and the drawbacks of conventional immunochromatographic sensors (ICS), including low sensitivity and non-intuitive signal outputs, a fluorescence-quenching ICS (FQICS) was developed. This sensor leverages fluorescence resonance energy transfer (FRET) between aggregation-induced emission fluorescent microspheres (AIEFMs) and gold nanoparticles (AuNPs).
View Article and Find Full Text PDFUnlocking High-Performance Electrochemiluminescence in Supramolecular Coordination Frameworks via π-Bridge Engineering and Aggregation.
Small
September 2025
School of Chemistry and Chemical Engineering, Key Lab of Fuel Cell Technology of Guangdong Province, South China University of Technology, Guangzhou, 510641, China.
Aggregation-induced electrochemiluminescence (AIECL) is a promising strategy for enhancing electrochemiluminescence (ECL) efficiency by minimizing energy loss of excited-state ECL emitters. However, rational design of high-efficiency AIECL emitters is hindered by limited mechanistic understanding and an unclear structure-performance relationship. To address this, four supramolecular coordination frameworks (SCFs) with varying π-bridge structures are synthesized using pyridine-functionalized tetraphenylethene (TPE) as the ligand and Pt(II) as the coordination center.
View Article and Find Full Text PDFEnhanced Sensitivity of Nonlinear Optical Signatures of Aggregation-Induced Emission.
J Am Chem Soc
September 2025
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Understanding how molecular aggregation influences nonlinear optical properties is essential for advancing organic fluorophores in imaging, sensing, and photonic applications. However, the relationship between the molecular aggregation and the magnitude of nonlinear two-photon absorption cross-section remains underexplored. Here, we systematically investigate the aggregation-dependent two-photon absorption properties of the fluorophore TPAPhCN by tuning the degree of aggregation.
View Article and Find Full Text PDFStrategic Design of Aptamer-Guided Aggregation-Induced Emission Nanoparticles for Targeted Photodynamic Therapy in Breast Cancer.
Adv Sci (Weinh)
September 2025
Department of Chemical and Biological Engineering, Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Hong Kong, 999077,
Breast cancer (BC), characterized by its heterogeneity and diverse subtypes, necessitates personalized treatment strategies. This study presents MF3Ec-TBPP nanoparticles (NPs) as a promising approach, integrating an aggregation-induced emission (AIE)-based photosensitizer, TBPP, with the MF3Ec aptamer to enhance targeted photodynamic therapy (PDT) for Luminal A subtype BC cells. The nanoparticles also feature a 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) shell and dipalmitoyl phosphatidylcholine (DPPC), which stabilize the structure and inhibit singlet oxygen generation, effectively reducing off-target effects and protecting healthy tissues.
View Article and Find Full Text PDFRecent Progress In Organic High-Temperature Photothermal Materials.
Chem Asian J
September 2025
School of Science and Engineering, Shenzhen Institute of Molecular Aggregate Science and Engineering, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, 518172, China.
Organic high-temperature photothermal materials (T > 100 °C) have demonstrated significant application values because of their ability to exceed the temperature limits of traditional organic photothermal materials, enabling spatiotemporally controllable long-distance heating and high-temperature conversion of laser or sunlight. In this review, we summarize the recent progress in organic high-temperature photothermal materials, mainly including organic small molecule and polymer materials. Their photothermal conversion mechanisms and the factors influencing their performance as well as their applications, including photo controlled ignition/deflagration, photothermal induced actuators, photo controlled metal processing, and concentrated sunlight energy conversion were elaborated.
View Article and Find Full Text PDF