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http://dx.doi.org/10.2459/JCM.0000000000001393 | DOI Listing |
Front Sports Act Living
August 2025
Department of Physical Education, Tianjin University of Sport, Tianjin, China.
Background: Repeated-sprint training in hypoxia (RSH) has emerged as a novel strategy to optimize repeated-sprint ability (RSA), aerobic capacity, and anaerobic performance in athletes. Although numerous studies have explored its efficacy compared with repeated-sprint training in normoxia (RSN), inconsistencies remain regarding overall benefits and modulating factors.
Objectives: This study aimed to quantify the overall effect of RSH vs.
Lupus
September 2025
Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
ObjectiveTo systematically compare the clinical effectiveness and safety of Belimumab, Rituximab and Voclosporin in the treatment of lupus nephritis based on network meta-analysis method.MethodsSystematic search of registered clinical trials in four major databases (Pubmed, Embase, Web of Science, The Cochrane Register of Clinical Trials) and ClinicalTrials.gov.
View Article and Find Full Text PDFCurr Med Chem
September 2025
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No.14, 3rd Section of Ren Min Nan Rd., Chengdu, 610041, China.
Introduction: Current osteoporosis medications often prove ineffective for various reasons. Alongside optimizing available agents, new genetic targets should be proposed for drug development. Mendelian randomization (MR) may resolve throughput and confounding issues in traditional observational studies for druggable targets.
View Article and Find Full Text PDFBlood Adv
September 2025
University of Granada, Granada, Alaska, Spain.
We investigated the influence of 55,583 autophagy-related single nucleotide polymorphisms (SNPs) on chronic lymphocytic leukemia (CLL) risk across four independent populations comprising 5,472 CLL cases and 726,465 controls. We also examined their impact on overall survival (OS), time to first treatment (TTFT), autophagy flux, and immune responses. A meta-analysis of the four populations identified, for the first time, significant associations between CDKN2A (rs3731204) and BCL2 (rs4940571, rs12457371, rs1026825) SNPs and CLL risk, with CDKN2A showing the strongest association (p=1.
View Article and Find Full Text PDFFront Cardiovasc Med
August 2025
Department of Cardiology, MedStar Heart and Vascular Institute, Washington, DC, United States.
Background: Cryoballoon (CB) ablation is a well-established treatment for atrial fibrillation (AF). The Arctic Front Advance Pro™ (AFA-Pro) system, in use for over a decade, has demonstrated consistent efficacy and safety. Recently, the POLARx™, a novel CB system, has gained attention due to its advanced design and comparable clinical outcomes.
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