Circulating proteins and bone mineral density: A Proteome-Wide Mendelian Randomization Study.

Introduction: Current osteoporosis medications often prove ineffective for various reasons. Alongside optimizing available agents, new genetic targets should be proposed for drug development. Mendelian randomization (MR) may resolve throughput and confounding issues in traditional observational studies for druggable targets.

Enhanced score-based priors-boosted generative model for resolution breakthrough in photoacoustic tomography.

Photoacoustic tomography (PAT), a non-invasive biomedical imaging modality, integrates optical contrast with acoustic depth resolution. However, industry-standard ultrasonic transducers exhibit limited bandwidth, inherently degrading image resolution in conventional reconstruction. To address this, we propose a sinogram-domain signal spectral reconstruction method based on an enhanced score-based diffusion model (ESDM).

Three-Dimensional Siamese Multi-Level Features Neural Network Based 3D Fusion Improves the Depth of Field in Photoacoustic Microscopy.

Microscopic imaging techniques pursue high-resolution, large depth of field (DoF) imaging but are limited by hardware, especially the strong focusing of objective lenses. Optical-resolution photoacoustic microscopy (OR-PAM) has a narrow DoF due to the intense laser focusing needed for high-resolution imaging. To address this, we propose a novel volumetric information fusion method using a three-dimensional siamese multi-level features convolutional neural network (3DSMFCNN) for cost-effective, large-DoF imaging.

Community health worker-led interventions for hypertension.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of community health worker-led interventions on controlling blood pressure for people with hypertension.

Neutrophil-derived serine proteases induce FOXA2-mediated autophagy dysfunction and exacerbate colitis-associated carcinogenesis via protease activated receptor 2.

Autophagy plays a critical role in colitis-associated colorectal cancer (CAC). However, non-autonomous regulation of macroautophagic/autophagic flux during inflammation remains largely unexplored. Here, we show that deficiency ([ΔIEC]) aggravated azoxymethane-dextran sulfate sodium-induced CAC based on tumor number and burden, promoted autophagy dysfunction characterized by SQSTM1/p62 accumulation and autophagosome-lysosome fusion inhibition in IECs, and reduced lysosomal acidification by suppressing FOXA2-induced V-ATPase transcription.

Estimation of direction and zero errors of satellite laser terminals in low-light conditions based on machine learning.

In the assembly, launch, and on-orbit operation of satellite optical communication terminals, small deviations are difficult to avoid, which can lead to pointing errors and challenges to the establishment of optical communication links. To estimate the pointing errors of on-orbit satellite terminals, a calibration algorithm is developed based on lunar surface imagery. First, a feature extraction algorithm for low-light images is employed to process consecutive frames of low-light images to obtain a lunar surface feature map.

A review of the roles of exosomes in salivary gland diseases with an emphasis on primary Sjögren's syndrome.

Salivary gland diseases encompass a broad range of conditions, including autoimmune, inflammatory, obstructive, and neoplastic disorders, significantly impacting oral health and overall well-being. Recent research has highlighted the crucial role of exosomes, small extracellular vesicles, in these diseases. Exosomes mediate intercellular communication by transferring bioactive molecules such as proteins, microRNAs, and lipids, positioning them as potential diagnostic biomarkers and therapeutic agents.

Application of Submandibular Intubation as Alternative to Elective Short-Term Tracheotomy for Particular Cases of Oral and Maxillofacial Tumors Resection and Defects Reconstruction.

Objective: To describe the cases of oral and maxillofacial tumors (OMFT) resection and defects reconstruction under submandibular intubation (SMI) performed in our institution; secondly, to systematically review and analyze the characteristics of studies about SMI in oral and maxillofacial surgery to estimate the incidence rate of complication.

Method: Data related to all 6 patients included in this study were prospectively collected from November 2016 to November 2023. The tract for endotracheal tube was created by bluntly dissection from the submandibular area to the floor of mouth.

Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China.

Background: Autogenous tooth transplantation offers significant advantages and promising success rates for replacing non-retainable teeth. This study aimed to investigate the prognostic factors, especially the impact of root canal treatment (RCT), of autotransplanted teeth in an up-to-6-year follow-up cohort of 167 teeth in Southern China.

Methods: We enrolled adult patients from the Southern Medical University-Shenzhen Stomatology Hospital between 2017 and 2023.

Ultra-sparse reconstruction for photoacoustic tomography: Sinogram domain prior-guided method exploiting enhanced score-based diffusion model.

Photoacoustic tomography, a novel non-invasive imaging modality, combines the principles of optical and acoustic imaging for use in biomedical applications. In scenarios where photoacoustic signal acquisition is insufficient due to sparse-view sampling, conventional direct reconstruction methods significantly degrade image resolution and generate numerous artifacts. To mitigate these constraints, a novel sinogram-domain priors guided extremely sparse-view reconstruction method for photoacoustic tomography boosted by enhanced diffusion model is proposed.

From anatomy to surgery: Effectiveness of virtual simulation adjuvant to traditional methods in the preclinical training of apicoectomy.

Anatomy forms the foundation for the training and execution of routine surgical procedures. However, a gap persists in effectively bridging anatomical knowledge with the confident performance of procedures. Virtual simulation (VS) techniques, based on experiential and situated learning theory, hold promise in addressing this challenge.

SCG2 Mediates HNSCC Progression With CCL2/TGFβ1 M2 Macrophage Infiltration.

Objectives: This study aims to unravel the mechanisms underlying M2 macrophage polarization in head and neck squamous cell carcinoma (HNSCC), and identify potential therapeutic targets.

Materials And Methods: We conducted an integrated bioinformatic analysis using HNSCC bulk transcriptomes from TCGA and GEO databases to pinpoint critical factors influencing M2 macrophage polarization and tumor prognosis. The significance of these genes was validated in function analysis, single-cell transcriptome datasets, and in vitro experiments.

ORAI2 is Important for the Development of Early-Stage Postirradiation Fibrosis in Salivary Glands.

Purpose: Although postirradiation hyposalivation significantly impairs patient quality of life, the underlying mechanisms driving radiation-induced salivary gland fibrosis and hyposalivation remain poorly understood. This study aims to explore the role of calcium-mediated signaling pathways in radiation-induced salivary gland fibrosis.

Methods And Materials: Primary human submandibular gland (SG) cells and C57BL/6J female mouse SGs were exposed to irradiation to model fibrosis development.

Holography optimization based on combining iterative Green's function algorithm and deep learning method.

In this Letter, we present a novel, to the best of our knowledge, approach that combines a new numerical iterative algorithm with a physics-informed neural network (PINN) architecture to solve the Helmholtz equation, thereby achieving highly generalized refractive index modulation holography. Firstly, we design a non-uniform refractive index convolutional neural network (NRI-CNN) to modify the refractive index and extract a feature vector. Then we propose an iterative Green's function algorithm (IGFA) to approximately solve the Helmholtz equation.

Dental caries and salivary alterations in patients with type 2 diabetes: A systematic review and meta-analysis.

Introduction: The association between dental caries, salivary alterations, and type 2 diabetes (T2D) is inconclusive. This systematic review evaluated the caries status and salivary alterations in adults with T2D.

Data: Observational studies (cross-sectional, case-control, or cohort studies) that evaluated the association between type 2 diabetes and dental caries and/or salivary changes were included.

Postextraction infections, prevention, and treatment.

Postoperative infection is one of the most common complications of tooth extraction. It may manifest as localized infection or develop to systemic infection. Clinically, oral surgeons can prevent postoperative infections by urging patients to strengthen oral hygiene, applying antibiotics in a rational and compliant manner, and choosing appropriate surgical methods for tooth extraction.

TGF-β1 maintains the developmental potential of embryonic submandibular gland epithelia separated with mesenchyme.

Objective: The objective of this study was to investigate the impact of transforming growth factor β1 (TGF-β1) on epithelial development using an ex vivo model of submandibular gland (SMG) epithelial-mesenchymal separation.

Materials And Methods: The ex vivo model was established by separating E13 mouse SMG epithelia and mesenchyme, culturing them independently for 24 h, recombining them, and observing branching morphogenesis. Microarray analysis was performed to evaluate the transcriptome of epithelia treated with and without 1 ng/ml TGF-β1.

Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009-2014.

Periodontitis is a cumulative inflammatory disease associated with multiple health conditions and various systemic diseases. As a common disease, virus infection along with its consequences has become a serious health burden. The study aims to evaluate the relationship between common viruses including hepatitis virus, human immunodeficiency virus (HIV), herpes simplex virus (HSV), human papillomavirus (HPV), and periodontitis.

DLX6-AS1 regulates odonto/osteogenic differentiation in dental pulp cells under the control of BMP9 via the miR-128-3p/MAPK14 axis: A laboratory investigation.

Aim: The regenerative capacity of dental pulp relies on the odonto/osteogenic differentiation of dental pulp cells (DPCs), but dynamic microenvironmental changes hinder the process. Bone morphogenetic protein 9 (BMP9) promotes differentiation of DPCs towards an odonto/osteogenic lineage, forming dentinal-like tissue. However, the molecular mechanism underlying its action remains unclear.

Efficient removal of allicin from the stalk of Allium fistulosum for dietary fiber production.

The stalk of Allium fistulosum contains dietary fibers with complicated monosaccharide composition and glycosidic bond linkages, which renders it a better dietary fiber supplement. However, the unfavorable odor, majorly contributed by allicin, limits its applications. Although many physical and chemical methods have been developed to remove allicin, there is currently no comparison between their efficiencies.

Electronic symptom monitoring for home-based palliative care: A systematic review.

Background: Coordination and communication challenges in home-based palliative care complicate transitions from hospital care. Electronic symptom monitoring enables real-time data collection, enhancing patient-provider communication. However, a systematic evaluation of its effectiveness in home-based palliative care is lacking.

Score-based generative model-assisted information compensation for high-quality limited-view reconstruction in photoacoustic tomography.

Photoacoustic tomography (PAT) regularly operates in limited-view cases owing to data acquisition limitations. The results using traditional methods in limited-view PAT exhibit distortions and numerous artifacts. Here, a novel limited-view PAT reconstruction strategy that combines model-based iteration with score-based generative model was proposed.

Understanding dilution effects on particle-containing pesticide droplets deposition on rice leaf via developing CFD-VOF-DPM model.

Background: Pesticide dilution is one of the essential aspects of plant protection. However, the effect of dilution on the deposition characteristics of pesticide droplets containing particulate additives on crop leaf surfaces remains unclear and warrants further research. Herein, a validated computational fluid dynamics (CFD)-volume of fluid (VOF)-discrete phase model (DPM) numerical model was developed to analyze the influence of particle content on the deposition behavior of droplets on the leaf surface comparatively, taking into account the particle content of different diluted thifluzamide solutions.

Evidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review.

Background: Experiences during childhood and adolescence have enduring impacts on physical and mental well-being, overall quality of life, and socioeconomic status throughout one's lifetime. This underscores the importance of prioritizing the health of children and adolescents to establish an impactful healthcare system that benefits both individuals and society. It is crucial for healthcare providers and policymakers to examine the relationship between COVID-19 and the health of children and adolescents, as this understanding will guide the creation of interventions and policies for the long-term management of the virus.