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http://dx.doi.org/10.1016/j.scib.2022.03.019 | DOI Listing |
Neurochem Int
September 2025
Department of Neurobiology, College of Basic Medicine, Key Laboratory of Molecular Neurobiology of Ministry of Education, Naval Medical University, Shanghai 200433, China. Electronic address:
Traditionally, oligodendrocyte precursor cells (OPCs) were primarily regarded for their differentiation potential to mature oligodendrocytes that ensheath central nervous system (CNS) axons through myelin formation. Recent breakthroughs in single-cell sequencing and in vivo imaging technologies have revolutionized our understanding, revealing that OPCs engage in extensive dynamic interactions with diverse CNS cell populations during neurodevelopment, tissue homeostasis maintenance, and pathological microenvironment remodeling. Notably, while OPCs exhibit relatively conserved phenotypic signatures, their functional plasticity within heterogeneous microenvironments demonstrates significant spatial specificity and disease-context dependence.
View Article and Find Full Text PDFAcc Chem Res
September 2025
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.
ConspectusHydroaminoalkylation, the catalytic addition of amines to alkenes, has evolved as a powerful tool in modern synthetic chemistry, offering an atom-economic and green approach to the construction of C-C bonds. This reaction enables the direct amine functionalization of alkenes and alkynes without the need for protecting groups, directing groups, or prefunctionalization, thereby eliminating stoichiometric waste and minimizing synthetic steps. Over the past two decades, significant advances in catalyst development and mechanistic understanding have expanded the scope of hydroaminoalkylation, allowing for control over regio-, diastereo-, and enantioselectivity.
View Article and Find Full Text PDFZhonghua Jie He He Hu Xi Za Zhi
September 2025
Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
Severe pneumonia remains a major threat to human health, particularly in patients who progress to sepsis, with immune dysregulation playing a central role in its pathophysiological mechanism. Although immunomodulatory therapies have evolved alongside our improved understanding of immune imbalance, conflicting clinical evidence persists. For example, agents targeting similar pathways may produce divergent outcomes, while those with opposing mechanisms of action may yield comparable results.
View Article and Find Full Text PDFAdv Mater
September 2025
Center of Electron Microscopy, State Key Laboratory of Silicon and Advanced Semiconductor Materials, School of Materials Science and Engineering, Zhejiang Key Laboratory of Low-Carbon Synthesis of Value-Added Chemicals, Zhejiang University, Hangzhou, 310027, China.
Electrocatalysis, a pivotal field at the intersection of physical chemistry and materials science, plays a crucial role in advancing energy conversion and storage technologies through rational catalyst design. However, understanding reaction mechanisms at the atomic level remains a great challenge due to the intricate interplay between catalysts, reactants, and complex environments (e.g.
View Article and Find Full Text PDFAlzheimers Dement
September 2025
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
This review covers recent advances (2023-2024) in neuroimaging research into the pathophysiology, progression, and treatment of Alzheimer's disease (AD) and related dementias (ADRD). Despite the rapid emergence of blood-based biomarkers, neuroimaging continues to be a vital area of research in ADRD. Here, we discuss neuroimaging as a powerful tool to topographically visualize and quantify amyloid, tau, neurodegeneration, inflammation, and vascular disease in the brain.
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