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Objectives: To describe the inpatient population, establish patterns in admission and mortality over a 4-year period in different cohorts and assess the prognostic ability and workload implications of introducing the National Early Warning Score 2 (NEWS2) and associated escalation protocol.
Design: Retrospective cohort analyses of medical and surgical inpatient admissions.
Setting: Large teaching hospital with tertiary inpatient care and a major trauma centre employing an electronic observations platform, initially with a local early warning score, followed by NEWS2 introduction in June 2019.
Participants: 332 682 adult patients were admitted between 1 January 2016 and 31 December 2019.
Outcome Measures: Mortality, workload and ability of early warning score to predict death within 24 hours.
Results: Admissions rose by 19% from 76 055 in 2016 to 90 587 in 2019. Total bed days rose by 10% from 433 382 to 477 485. Mortality fell from 3.7% to 3.1% and was significantly lower in patients discharged from a surgical specialty, 1.0%-1.2% (p<0.001). Total observations recorded increased by 14% from 1 976 872 in 2016 to 2 249 118 in 2019. 65% of observations were attributable to patients under medical specialties, 34% to patients under surgical specialties. Recorded escalations to the registrar were stable from January 2016 to May 2019 but trebled following the introduction of NEWS2 in June 2019.
Conclusions: There was an increase in hospital inpatient activity between 2016 and 2019, associated with a reduction in mortality and percentage of observations calculated as reaching threshold NEWS2 score of 7 for escalation to the registrar. The introduction of the NEWS2, with a higher sensitivity and lower specificity, when allied to its escalation protocol, was associated with a significant increase in actual recorded escalations to the registrar. This was more marked in the surgical population and would support refining threshold scores based on admission characteristics when developing the next iteration of NEWS.
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http://dx.doi.org/10.1136/bmjopen-2022-064579 | DOI Listing |
Br J Nurs
September 2025
Professor, Department of Digestive Diseases, Transplantation and General Surgery, Copenhagen University Hospital Rigshospitalet/Department of Clinical Medicine, University of Copenhagen, Denmark.
Introduction: Approximately 1 million people live with ileostomies and rely on stoma bags in their daily lives. They do not have access to alternative products. To address alternatives, InterPoc™, an absorbent intestinal tampon, has been developed.
View Article and Find Full Text PDFJ Hazard Mater
September 2025
State Key Laboratory of Nutrient Use and Management, Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China.
Cadmium (Cd) contamination in vegetables poses a potential risk to human health; thus an accurate soil Cd threshold is crucial for early warning to ensure safe production. In this study, a national-scale dataset of Cd contents in agricultural soils and vegetables in China was compiled to assess the dietary exposure risk, and a hybrid approach combining conditional inference trees (CITs) and species sensitivity distribution (SSD) was established to derive soil Cd thresholds. The results showed that amaranth, butterhead lettuce, Chinese cabbage, coriander, and garlic had higher Cd accumulation ability among 34 species studied.
View Article and Find Full Text PDFAnal Chim Acta
November 2025
College of Chemical Engineering, Xiangtan University, Xiangtan, 411105, China. Electronic address:
Background: Aflatoxin B1 (AFB1) is a highly carcinogenic mycotoxin frequently found in contaminated food products, posing a significant threat to public health and food safety. Therefore, the development of rapid, sensitive, and reliable detection methods for AFB1 is critical for early warning and prevention. However, traditional detection techniques often require expensive equipment, skilled personnel, and complex procedures, limiting their suitability for on-site applications.
View Article and Find Full Text PDFSci Total Environ
September 2025
European Commission, Joint Research Centre (JRC), Ispra, Italy. Electronic address:
Drought stress has profound impacts on ecosystems and societies, particularly in the context of climate change. Traditional drought indicators, which often rely on integrated water budget anomalies at various time scales, provide valuable insights but often fail to deliver clear, real-time assessments of vegetation stress. This study introduces the Cooling Efficiency Factor Index (CEFI), a novel metric purely derived from geostationary satellite observations, to detect vegetation drought stress by analyzing daytime surface warming anomalies.
View Article and Find Full Text PDFWater Res
August 2025
Department of Environmental Science, Hankuk University of Foreign Studies, 81 Oedae-ro, Mohyeon-eup, Cheoin-gu, Yongin-si 17035, South Korea. Electronic address:
The application of metabolomics to the water quality monitoring system, biological early warning system (BEWS), has been proposed; however, its development has not been attempted due to challenges such as high inter-individual variability and invasive sampling requirements in metabolomics applications. In this study, we employed an extracellular metabolomics (exo-metabolomics) approach using Daphnia magna to overcome these limitations and evaluate its utility in field river water conditions. From BEWS flow-through chambers, we collected exo-metabolites under ambient, copper exposure (0-80 μg/L), and post-exposure conditions.
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