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Article Abstract
Eukaryotic gene expression is regulated through chromatin conformation, in which enhancers and promoters physically interact (E-P interactions). How such chromatin-mediated E-P interactions affect gene expression is not yet fully understood, but the roles of histone acetylation and methylation, pioneer transcription factors, and architectural proteins such as CCCTC binding factor (CTCF) and cohesin have recently attracted attention. Moreover, accumulated data suggest that E-P interactions are mechanistically involved in biophysical events, including liquid-liquid phase separation, and in biological events, including cancers. In this review, we discuss various mechanisms that regulate eukaryotic gene expression, focusing on emerging views regarding chromatin conformations that are involved in E-P interactions and factors that establish and maintain them.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659172 | PMC |
| http://dx.doi.org/10.3390/cancers14215404 | DOI Listing |
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Article Synopsis
- Anaplastic thyroid carcinoma (ATC) is a rare and serious type of cancer that affects the thyroid gland, and researchers are studying a protein called DIAPH3 to see how it affects this cancer.
- They used different tests to find out how DIAPH3 interacts with another protein, FOXM1, and how this affects cancer cells' ability to grow and spread.
- The results showed that DIAPH3 helps ATC cells become more aggressive and that it works with FOXM1 to promote cell growth and prevent cell death, making the cancer harder to treat.