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A 41 years old male patient, having acute respiratory distress syndrome (ARDS) due to viral pneumonia, was put on venovenous (VV) extracorporeal membrane oxygenation (ECMO). After 3 h of initiation, the ECMO pump malfunctioned. The patient was initially managed on a hand crank for 5 h. However, as another machine would be available after 12-24 h, we decided to use a roller pump with a conventional cardiopulmonary bypass (CPB) circuit. We successfully manage this crisis with this technique without any complications. This technique can be lifesaving in catastrophic situations such as ECMO console or pump failures when there are neither backup machines nor service engineers available.
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http://dx.doi.org/10.1007/s12055-022-01405-3 | DOI Listing |
Biotechnol J
August 2025
School of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin, China.
Extracorporeal membrane oxygenation (ECMO) is a fundamental treatment for cardiovascular and severe pulmonary diseases, with small animal models providing critical insights into organ protection during cardiopulmonary bypass and ECMO therapy. Conventional roller pumps, however, induce hemolysis and organ injury through repetitive compression-shear exposure, severely limiting their utility. While centrifugal pumps reduce shear stress and are effective in large animal ECMO, their flow range and priming volume are unsuitable for small animals.
View Article and Find Full Text PDFClin Drug Investig
August 2025
Pharmacokinetics Division, Pharmaceutical Technology Department, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Background: An extracorporeal membrane oxygenation (ECMO) device represents an additional functional body compartment, potentially impacting vancomycin pharmacokinetics.
Objectives: This systematic review aimed to: (1) provide a comprehensive summary of vancomycin population pharmacokinetics (Pop-PK) in critically ill patients receiving ECMO and; (2) associate the findings with clinical practices and dosing recommendations.
Methods: PubMed, Embase and Google Scholar databases were searched for vancomycin non-linear mixed-effects modelling Pop-PK studies in ECMO patients (inception-May 2024).
J Artif Organs
July 2025
Devision of Cardiovascular Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto City, Nagano, 390-8621, Japan.
To determine the optimal perfusion volume for the celiac artery (CA) and superior mesenteric artery (SMA) in a porcine model. Fifteen Yorkshire pigs (46.7 ± 5.
View Article and Find Full Text PDFPerfusion
July 2025
Division of Cardiovascular Perfusion, College of Health Professions, Medical University of South Carolina, Charleston, SC, USA.
PurposeThis study examined the pressure drop across several LV vent catheters commonly used in adult and pediatric cardiac surgery to identify optimal vent catheters for different flows that may be required based on patient and surgical specific factors.MethodsIn an experimental set up, 5 sizes of Medtronic DLP Left Heart vent catheters (10Fr, 13Fr, 15Fr, 18Fr, and 20Fr) were tested using a blood analogous solution. Flow was increased incrementally by either 5 or 10 RPMs on a roller pump and measured using a non-invasive flow sensor.
View Article and Find Full Text PDFScand Cardiovasc J
December 2025
School of General Practice, Guangxi Medical University, Nanning, China.
. In this study, we investigated the different effects of roller and centrifugal pumps on blood and myocardial tissue structure in a normothermic machine-perfused porcine heart model. .
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