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http://dx.doi.org/10.1530/RAF-22-0036 | DOI Listing |
Ann Med Surg (Lond)
September 2025
YunFu People's Hospital, Yunfu, China.
Introduction And Importance: Ovarian tumors are relatively rare in children and adolescent females, with mixed sex-cord-stromal tumors being a specific subtype that has a low incidence and is associated with DICER1 gene mutations.
Case Presentation: This case report describes a 14-year-old female patient diagnosed with a mixed sex-cord-stromal tumor associated with a DICER1 gene mutation, who had a rapid recurrence. The patient did not receive standardized chemotherapy after the initial surgery, and the tumor recurred within 6 months, leading to a second surgery and chemotherapy.
Anal Methods
September 2025
School of Biotechnology, Jiangnan University, Wuxi 214122, China.
In recent years, the decline in ovarian reserve function has become a major cause of reduced female fertility. Early identification, evaluation, and management of ovarian reserve dysfunction are essential for improving female fertility and reproductive health. Currently, the main diagnostic method is assessing ovarian function through measuring AMH serum concentration and follicle count.
View Article and Find Full Text PDFFront Immunol
August 2025
Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Autoimmune encephalitis (AE) is a heterogeneous disorder mediated by autoantibodies targeting neuronal or glial antigens, with anti-NMDAR encephalitis being the most common subtype, while cases with dual antibody positivity remain exceedingly rare. Standard treatment involves stepwise immunotherapy, but refractory cases often require advanced therapies. This study presents the first reported case of dual anti-NMDAR and anti-GFAP antibody-positive refractory AE in a 24-year-old female who failed first-line treatments (steroids, IVIG) and ovarian teratoma resection.
View Article and Find Full Text PDFPharmaceutics
August 2025
OnCusp Therapeutics, 433 Broadway, New York, NY 10013, USA.
Cadherin-6 (CDH6), also known as K-cadherin, is a type II classic cadherin molecule that plays an important role in the embryonic development of the kidney but has very limited expression in adult tissues. It is overexpressed in several human malignancies, primarily in ovarian cancer, renal cell carcinoma, as well as, less frequently, cholangiocarcinoma, uterine serous carcinoma, glioma, lung, pancreatic and thyroid cancers. The characteristic of limited expression in normal tissues, high expression in tumor tissues, and rapid internalization upon antibody binding makes CDH6 a well-suited antibody-drug conjugate (ADC) target.
View Article and Find Full Text PDFLab Chip
August 2025
MOE Key Laboratory of Intelligent Biomanufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, PR China.
The aberrant expression of RNAs in ovarian cancer (OC) progression highlights their potential as clinical biomarkers. However, rapid and accurate quantification of these RNAs in biosamples remains a significant challenge. In this study, we develop a modular isothermal rolling circle amplification (RCA)-activated Cas12a loop-enhanced (MIRACLE) amplification method for circRNA and miRNA quantification without the need of reverse transcription.
View Article and Find Full Text PDF