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Diabetes and prediabetes (called abnormal glucose regulation (AGR)) are adverse health effects associated with exposure to pesticides. However, there are few epidemiological studies on the relationship between pesticide use and the incidence of AGR. We examined the causal relationship between pesticide use and AGR incidence in a rural population using data from a Korean Farmers' Cohort study of 1076 participants. Poisson regression with robust error variance was used to calculate the relative risks (RR) and 95% confidence intervals (CI) to estimate the relationship between pesticide exposure and AGR. The incidence of AGR in the pesticide-exposed group was 29.1%. Pesticide use increased the RR of AGR (RR 1.32, 95% CI 1.03-1.69). We observed a low-dose effect related to exposure of pesticides to AGR and a U-shaped dose-response relationship in men. Pesticide exposure is related to the incidence of AGR, and the causal relationship differs between men and women.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223857 | PMC |
http://dx.doi.org/10.3390/ijerph19127550 | DOI Listing |
Nan Fang Yi Ke Da Xue Xue Bao
August 2025
Key Laboratory of Occupational Environment and Health, Guangzhou Twelfth People's Hospital, Guangzhou 510620, China.
Objectives: To investigate the role of ferroptosis in diquat-induced acute kidney injury (AKI) and its molecular mechanisms.
Methods: Transgenic zebrafish models with Tg (Eco.Tshb:EGFP) labeling of the renal tubules and Tg (lyz:dsRed2) labeling of the neutrophils were both divided into control group, gentamicin (positive control) group, diquat poisoning group, ferroptosis inhibitor group.
J Hazard Mater
September 2025
Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing RD 18, Beijing 100085, China; University of Chinese Academy of Sciences, Yuquan RD 19 a, Beijing 100049, China. Electronic address:
Epoxiconazole (EPX) is widely applied to control various fungal diseases in crops. However, the toxicological effects of EPX on reptiles remain unknown, especially at the enantiomer level. In this study, lizards were repeatedly exposed to rac-EPX, (+)-EPX, and (-)-EPX at doses of 10 and 100 mg/kg bw for 21 days.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
Marine College, Shandong University, Weihai, Shandong 264209, China. Electronic address:
Tralopyril (TP), a representative bromopyrrolonitrile, functions as a broad-spectrum insecticide, raising growing concerns about its potential impact on aquatic organisms and human intestinal health. However, the key targets and toxicity mechanisms underlying TP-induced enteritis remain unclear. In this study, we utilized network toxicology combined with molecular docking to comprehensively explore the potential molecular mechanisms underlying TP-induced enteritis.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
College of Plant Protection, Yangzhou University, Yangzhou 225009, China; Jiangsu Province Engineering Research Center of Green Pesticides, Yangzhou University, Yangzhou 225009, China. Electronic address:
Spodoptera frugiperda (FAW) is a notorious polyphagous pest that has developed resistance to various insecticides including diamide insecticides. Our previous study established a FAW cyantraniliprole-resistant (SfCYAN-R) strain by laboratory resistance selection of susceptible strain (SfCYAN-S), however, the potential resistance mechanisms of FAW to cyantraniliprole remain unclear. In this study, SfNrf6 encoding nose resistant to fluoxetine (Nrf) protein 6 was identified to be upregulated in SfCYAN-R strain compared with SfCYAN-S strain based on RNA-Seq data and RT-qPCR.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
College of Life Sciences, Chongqing Normal University, Chongqing, China; Key Laboratory of Pollinator Resources Conservation and Utilization of the Upper Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing, China; Chongqing Key Laboratory of Vector Control and Utilization, Chongqing,
As key pollinators, bees are increasingly threatened by environmental stressors such as heavy metals, pesticides, and temperature fluctuations, which can cause oxidative stress and disrupt cellular homeostasis. Glutathione S-transferases (GSTs) play crucial roles in antioxidant defense and detoxification, yet systematic studies on bee GST families remain limited. Here, we conducted a genome-wide analysis of cytosolic GST genes in 13 bee species, identifying 146 genes in total.
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