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Article Abstract
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170602 | PMC |
| http://dx.doi.org/10.1016/j.gendis.2021.10.001 | DOI Listing |
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Article Synopsis
- Penile squamous cell carcinoma (PSCC) is on the rise, especially in developing countries, and the role of long non-coding RNAs (lncRNAs) in its progression is not well understood.
- Researchers performed lncRNA sequencing on tissue samples to create a competing endogenous RNA (ceRNA) network that includes 4 lncRNAs, 18 miRNAs, and 38 mRNAs, all linked to PSCC.
- The study found that specific lncRNAs are upregulated in PSCC, correlating with overexpression of certain genes related to cell proliferation and an increase in immune cell infiltration, which could help explain PSCC’s relationship with the tumor microenvironment.