Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Aminoacyl-tRNA synthetases (ARSs) are emerging as important regulators in various immune diseases; however, their roles in immune cells remain unclear. In this study, using alanyl-tRNA synthetase (AARS) mutant (sti) mice with neurodegenerative disorder, we investigated the effect of translational fidelity in immune cells. Dysfunctional AARS caused disorders in immune cell responses and cellularity. The impairment was caused by dampened TCR signaling than cytokine signaling. Therefore, sti mutant inhibits TCR signaling, impeding T cell survival and responses. B cell numbers were decreased in sti mice. Despite low B cell cellularity, serum IgM, IgA, and IgE levels were higher in sti mice than in wild-type mice. Misacylation of ARS and the consequent translational infidelity induce disturbances in signaling pathways critical for immune cell survival and responses. Our findings provide a novel mechanism by which translational fidelity might play a critical role in cellular and humoral immune responses.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11071942 | PMC |
| http://dx.doi.org/10.1007/s00018-021-04122-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bidirectional optimization of firing rate in a mouse neuronal brain-machine interface.
Biol Lett
September 2025
State Key Laboratory of Digital Medical Engineering Sanya Research Institute of Hainan University, Hainan University, Haikou, Hainan, China.
Neuroplasticity enables the brain to adapt neural activity, but whether this can be harnessed for abstract optimization tasks like seeking curve extrema remains unclear. Here, we used a brain-machine interface in mice, pairing auditory feedback of neuronal firing rate with water rewards, to investigate whether motor cortex neurons can optimize activity along a unimodal curve ([Formula: see text]). The curve maps firing rate ([Formula: see text]) to sound frequency increase speed ([Formula: see text]), where the curve extremum accelerates reward acquisition.
View Article and Find Full Text PDFMicroRNA-21-5p from induced pluripotent stem cells promotes neuroprotection of retinal ganglion cells in optic nerve crush model.
BMC Ophthalmol
August 2025
Shanghai Key Laboratory of Visual Impairment and Restoration, Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Introduction: Retinal ganglion cells (RGCs) are susceptible to degenerative conditions such as glaucoma and traumatic optic neuropathies, which lead to vision loss. MicroRNA-21-5p has demonstrated potential neuroprotective effects, but its mechanisms in optic nerve injury remain underexplored. This study evaluates the neuroprotective role of microRNA-21-5p derived from induced pluripotent stem cells (iPSCs) in an optic nerve crush (ONC) model.
View Article and Find Full Text PDFA MeA Tac1 neural circuit mediates anxiety-like behaviors in mice.
EMBO Rep
September 2025
Key Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, 130021, Changchun, China.
Anxiety is an emotion characterized by worried thoughts and feelings of unease, often accompanied by physical symptoms such as sweating and dizziness. Unlike other negative emotions, the neural circuits underlying anxiety are not well understood. Here we report that Tachykinin Precursor 1 (Tac1)-expressing neurons in the medial amygdala (MeA) respond to the transition from high anxiety to low anxiety states.
View Article and Find Full Text PDFAcetate Administration Ameliorates Streptozotocin-Induced Hyperglycemia and Adipose Tissue Loss.
FASEB J
July 2025
Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Cambridge-Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Short-chain fatty acids (SCFAs) are products of gut microbiota through fermentation of soluble fibers. Recent studies have highlighted the beneficial roles of SCFAs in various physiological and pathological conditions, including diabetes. In this study, we applied streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) to investigate the potential role of SCFAs in the pathogenesis of T1DM.
View Article and Find Full Text PDFOxytocin Intervention Mitigates Pathological and Behavioral Impairments in APP/PS1 Mice Subjected to Early Social Isolation.
CNS Neurosci Ther
July 2025
Department of Neurosurgery, Sichuan Provincial People's Hospital, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Background: Neuropsychiatric symptoms, such as anxiety and depression, are prevalent during the prodromal phase of Alzheimer's disease (AD). Social isolation (SI) has been implicated as a potential exacerbating factor for emotional disturbances in AD pathogenesis. Despite the well-established role of oxytocin (OXT) in regulating social behavior and mental health, its function and mechanisms in alleviating AD-related psychiatric symptoms remain poorly understood.
View Article and Find Full Text PDF