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Natural polymers have emerged as promising candidates for the sustainable development of materials in areas ranging from food packaging and biomedicine to energy storage and electronics. In tandem, there is a growing interest in the design of advanced materials devised from naturally abundant and renewable feedstocks, in alignment with the principles of Green Chemistry and the 2030 Agenda for Sustainable Development. This review aims to highlight some examples of the research efforts conducted at the Research Team BioPol4fun, Innovation in BioPolymer-based Functional Materials and Bioactive Compounds, from the Portuguese Associate Laboratory CICECO-Aveiro Institute of Materials at the University of Aveiro, regarding the exploitation of natural polymers (and derivatives thereof) for the development of distinct sustainable biobased materials. In particular, focus will be given to the use of polysaccharides (cellulose, chitosan, pullulan, hyaluronic acid, fucoidan, alginate, and agar) and proteins (lysozyme and gelatin) for the assembly of composites, coatings, films, membranes, patches, nanosystems, and microneedles using environmentally friendly strategies, and to address their main domains of application.
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http://dx.doi.org/10.3390/molecules27010094 | DOI Listing |
Int J Nanomedicine
September 2025
Department of Pharmaceutics and Pharmaceutical Technology, Universitas Padjadjaran, Sumedang, West Java, 45363, Indonesia.
Background: Candidiasis, predominantly caused by , poses a significant global health challenge, especially in tropical regions. Nystatin is a potent antifungal agent that is hindered by its low solubility and permeability, limiting its clinical efficacy.
Methods: This study aimed to investigate the potential of a layer-by-layer (LBL) coating system, employing chitosan and alginate, to improve the stability, entrapment efficiency (%EE), and antifungal efficacy of nystatin-loaded liposomes against Candida albicans.
Chem Soc Rev
September 2025
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, 210037, China.
As concern for environmental sustainability continues to grow, wood, as a renewable resource and a composite of natural polymers (cellulose, hemicellulose, and lignin), has garnered increasing research attention. Traditional wood may have certain limitations in specific applications, such as being susceptible to moisture and biological degradation, as well as shortcomings in strength and durability. Therefore, wood modification has become a crucial strategy to enhance its performance and broaden its range of applications.
View Article and Find Full Text PDFCNS Neurol Disord Drug Targets
September 2025
College of Pharmacy, National University of Science and Technology, Muscat, Oman.
Neurological disorders are complex conditions characterized by impairment of the nervous system, affecting motor, cognitive, and sensory functions. Current treatments meet substantial obstacles, primarily due to the difficulty of transporting drugs across the blood-brain barrier and ineffective therapy for nerve regeneration. Emerging technologies, such as electrospinning, offer innovative solutions to overcome these challenges.
View Article and Find Full Text PDFFEBS Open Bio
September 2025
Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
The global accumulation of plastic waste, exceeding 360 million tonnes annually, represents a critical environmental challenge due to their widespread use and extreme recalcitrance in natural environments. Furthermore, the end-of-life processing of bioplastics, which are often marketed as eco-friendly, remains problematic, with biodegradation often requiring industrial conditions. Enzyme-based depolymerization of polyesters, such as polyethylene terephthalate (PET) and bioplastics (e.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Photo-responsive systems provide a powerful tool to reversibly regulate enzyme activity. However, inhibitor-based strategies, though widely used, are often restricted to specific enzymes. Noninhibitor strategies, such as enzyme surface modification or genetic mutation, often compromise structural integrity or residual activity.
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