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This review comprehensively summarizes epidemiologic evidence of COVID-19 in patients with Type 2 diabetes, explores pathophysiological mechanisms, and integrates recommendations and guidelines for patient management. We found that diabetes was a risk factor for diagnosed infection and poor prognosis of COVID-19. Patients with diabetes may be more susceptible to adverse outcomes associated with SARS-CoV-2 infection due to impaired immune function and possible upregulation of enzymes that mediate viral invasion. The chronic inflammation caused by diabetes, coupled with the acute inflammatory reaction caused by SARS-CoV-2, results in a propensity for inflammatory storm. Patients with diabetes should be aware of their increased risk for COVID-19.
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http://dx.doi.org/10.1016/j.pcd.2021.08.014 | DOI Listing |
Nutr Health
September 2025
Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
BackgroundCoronavirus Disease 2019 (COVID-19) has led to dramatic changes including social distancing, closure of schools, travel bans, and issues of stay-at-home orders. The health-care field has been transformed with elective procedures and on-site visits being deferred. Telemedicine has emerged as a novel mechanism to continue to provide care.
View Article and Find Full Text PDFDev World Bioeth
September 2025
Faculty of Law, University of Alberta, Edmonton, Alberta, Canada.
This article explores two complementary strategies for addressing the affordability and access challenges facing advanced therapies. As high development costs and limited market access have led to the withdrawal of several therapies, the article examines how these barriers create 'valleys of death' that prevent innovation from reaching patients. Through the case of Glybera and other examples, it outlines a rehabilitative approach focused on reforming current systems through improved reimbursement schemes, regulatory streamlining, and more efficient manufacturing.
View Article and Find Full Text PDFMinerva Anestesiol
September 2025
Tropical Biome et Immunopathologie CNRS UMR-9017, INSERM U1019, Université de Guyane, Cayenne, French Guiana.
Background: Extended delays in non-elective surgeries have been associated with suboptimal outcomes. The SARS-CoV-2 pandemic forced healthcare systems to adapt their setups for unscheduled procedures, leading, in our institution, to a reorganization from a setup with two dedicated operating rooms (ORs) at a central facility without dedicated teams to a temporary one with both dedicated teams and ORs during lockdown phase. This study evaluates the impact of this transitions on the time to surgery considering unscheduled procedures.
View Article and Find Full Text PDFInfect Control Hosp Epidemiol
September 2025
Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Background: Admission to shared hospital rooms are a risk factor of healthcare-associated (HA) SARS-CoV-2. Quantifying the impact of engineering controls such as ventilation and filtration is essential to informing resource utilization and infection prevention guidelines.
Methods: Multicenter test-negative study of patients exposed to SARS-CoV-2 in shared rooms across five hospitals between January and October, 2022.
Infect Control Hosp Epidemiol
September 2025
Department of Medicine, University Health Network, Toronto, Ontario, Canada.
Objective: To describe trends in the prevalence of healthcare-associated infections (HAIs) and antibiotic-resistant organisms (AROs) in Canadian acute-care hospitals.
Design: Repeated point prevalence surveys.
Setting: Canadian Nosocomial Infection Surveillance Program (CNISP) hospitals.