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Poor sleep is prevalent among caregivers of persons living with dementia and increases their risk for cognitive impairment and decline. In this cross-sectional, correlational study, we compared the cognitive function scores of caregivers with poor sleep with the demographically adjusted normed scores of the National Institutes of Health Toolbox Cognition Battery. Caregivers completed a 14-day sleep diary. On average, caregivers (n = 28) were 65.14 (±10.08) years, female, and White. Their average crystallized cognitive function composite score was significantly higher and their average fluid cognitive function composite score was significantly lower than the normative scores. Caregivers performed significantly worse on the processing speed domain measure. Poor sleep may affect how caregivers, including highly educated caregivers, process and respond to information, thus can influence how they safely perform complex caregiving tasks. Health care providers should consistently assess caregivers' sleep and cognitive abilities to promptly identify changes and provide timely interventions.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112431 | PMC |
http://dx.doi.org/10.1177/01939459211041163 | DOI Listing |
Brain Behav
September 2025
Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Background And Purpose: White matter hyperintensity (WMH) impairs cognitive function but is not evident in the early stage, raising the need to explore the underlying mechanism. We aimed to investigate the potential role of network structure-function coupling (SC-FC coupling) in cognitive performance of WMH patients.
Methods: A total of 617 participants with WMH (mean age = 61 [SD = 8]; 287 females [46.
Brain Behav
September 2025
Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
Purpose: Postoperative delirium (POD) remains poorly understood in terms of predictors and underlying mechanisms. This review summarized emerging evidence on the association between brain microstructural alterations and POD.
Method: This is a narrative review, describing the microstructural changes in aging brain, microstructural MRI findings, relationship among microstructural alterations, cognitive reserve and POD, and potential interventions targeting microstructure.
Brain Behav
September 2025
School of Pharmacy and Medical Technology, Putian University, Putian, China.
Background: Recent research has started to uncover an important connection between immune system activity and cognitive abilities. Although correlative associations have been documented, the causal mechanisms connecting specific immune cell subpopulations to cognitive capabilities remain insufficiently characterized. Our research aimed to determine directional relationships between distinct immune cell subtypes and cognitive function, potentially identifying targets for immunomodulatory interventions.
View Article and Find Full Text PDFBrain Behav
September 2025
School of Physical Education and Health, Henan University of Chinese Medicine, Zhengzhou, China.
Background: Clinical and basic research suggests that exercise is a safe behavioral intervention and effective in improving cognition in vascular dementia (VD). However, despite global efforts, there is still no effective method to completely cure VD. This study aimed to investigate the effects of long-term exercise pretreatment on typical VD pathology in a rat model, and further compare the neuroprotective impacts of different exercise modalities on VD rats.
View Article and Find Full Text PDFMol Ther
September 2025
Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610054, China; Laboratory of Aging Research, School of Medicine, University of Electronic Science and Technology of China, Chengdu
Brain aging is a major risk factor for cognitive decline and neurodegenerative diseases, driven by synaptic loss, reduced synaptic function, and inflammation. However, the molecular mechanisms underlying these dysfunctions remain unclear. Here, we conducted comparative transcriptomic analyses of brain regions (cortex and hippocampus) and kidney tissues, a peripheral organ with documented age-related dysfunction.
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