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Introduction: Medialization laryngoplasty with autologous fat (MLA) is indicated in some patients with glottic insufficiency. The approach is usually safe but long-term complications are poorly described.
Case Report: We present the history of a patient who developed progressive dyspnea and dysphonia two decades after bilateral MLA, which were due to the development of laryngea lipoma into the site of fat injection.
Discussion: The potential relationship between MLA and the development of laryngeal lipoma was discussed. The lipoma may be a long-term survival of too much fat tissue, which was reorganized into a well-limited lipoma over the long-term. Another hypothesis consisted of the injection of fat tissue, including fatty stem cells, and the development of a lipoma over the year through the neovascularization process.
Conclusion: We reported the first case of lipoma developed into the laryngeal site of fat injection. Future studies are needed to explore the long-term evolution of injected fat tissue in the context of MLA.
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http://dx.doi.org/10.1016/j.jvoice.2021.06.030 | DOI Listing |
J Sci Food Agric
September 2025
Graduate School of Environmental and Human Sciences, Meijo University, Nagoya, Japan.
Background: Astaxanthin Z-isomers have attracted much attention because recent studies have demonstrated that they exhibit greater bioavailability and biological activity than the naturally predominant all-E-isomer. However, the plasma appearance and tissue distribution of astaxanthin isomers when administered with a diet rich in astaxanthin Z-isomers are largely unknown. To understand the health benefits and safety of astaxanthin Z-isomers, it is important to study the in vivo kinetics of the isomers.
View Article and Find Full Text PDFLife Sci
September 2025
Department of Experimental Medical Science, Faculty of Medicine, Lund University, 221 84, Lund, Sweden; Wallenberg Center for Molecular Medicine, Faculty of Medicine, Lund University, 221 84, Lund, Sweden. Electronic address:
Aims: Experimental evidence suggests an important role for sphingosine-1-phosphate (S1P) and its generating enzymes sphingosine kinase 1/2 (SphK1/2) in obesity. We and others have shown that plasma S1P levels are elevated in obese mice and humans. Preclinical studies suggest that genetic SphK2 ablation in mice protects from age- and diet-induced obesity and metabolic dysfunction.
View Article and Find Full Text PDFJ Insect Physiol
September 2025
Mitrani Department of Desert Ecology, Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben Gurion 8499000, Israel. Electronic address:
Cellulose and chitin are the two most abundant polysaccharides on Earth. To digest these structural carbohydrates, herbivorous and omnivorous insects typically rely on cellulases, while insectivorous species often express chitinases. The American cockroach (Periplaneta americana), an extreme generalist omnivore, is known to thrive on a variety of diets.
View Article and Find Full Text PDFEcotoxicol Environ Saf
September 2025
Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address:
Radiofrequency electromagnetic radiation (RF-EMR) is ubiquitous in daily life, and the complexity of the electromagnetic environment continues to increase. Nevertheless, research on the biological effects of compound radiofrequency radiation-particularly its influence on lipid metabolism under realistic exposure scenarios-remains limited, and the underlying mechanisms are not yet fully elucidated. To investigate the impact of compound radiofrequency radiation on lipid metabolism, multi-frequency radiation exposure model both normal and obese mice were established.
View Article and Find Full Text PDFBiochem Biophys Res Commun
September 2025
Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, PR China. Electronic address:
Epidemiological studies have reported that social isolation increases the risk of diabetes, but the underlying neural mechanism remains unclear. Using a long-term single-housed (SH) mouse model of social isolation, SH mice not only exhibited disrupted glucose homeostasis, evidenced by elevated fasting glucose, impaired glucose tolerance, and reduced insulin sensitivity, but also showed hypertrophic adipocytes and altered lipid metabolism. To elucidate the neural mechanisms underlying these metabolic disturbances, retrograde trans-synaptic tracing revealed the paraventricular nucleus (PVN) and locus coeruleus (LC) as the most PRV-labeled brain regions, suggesting their potential roles in social isolation-induced hyperglycemia.
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