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Splenic erythrophagocytosis is regulated by ALX/FPR2 signaling.
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Maintaining a healthy pool of circulating red blood cells (RBCs) is essential for adequate perfusion, as even minor changes in the population can impair oxygen delivery, resulting in serious health complications including tissue ischemia and organ dysfunction. This responsibility largely falls to specialized macrophages in the spleen, known as red pulp macrophages, which efficiently take up and recycle damaged RBCs. However, questions remain regarding how these macrophages are acutely activated to accommodate increased demand.
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Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, School of Physics and Electronic Engineering, Harbin Normal University, Harbin 150025, China.
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View Article and Find Full Text PDFSignificantly enhanced effects of heavy metals on the toxicity, bioconcentration and biomagnification under combined exposure.
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Heavy metal (HM) co-contamination is prevalent in the aquatic ecosystems and often induces complex combined effects such as synergism or antagonism, bioconcentration and biomagnification on the food-chain organisms, which is threatening the survival of living creatures and even to human health. However, the combined effects of HMs under combined exposure on the aquatic food chains still remain poorly understood. Therefore, toxic responses, bioconcentration and biomagnification of four typical HMs, lead (Pb), cadmium (Cd), nickel (Ni) and zinc (Zn), were systematically investigated under different combined exposure conditions.
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