Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Restricted or enhanced intrauterine growth is associated with elevated risks of early and late metabolic problems in humans. Metabolomics based on amino acid and carnitine/acylcarnitine profile may have a role in fetal and early postnatal energy metabolism. In this study, the relationship between intrauterine growth status and early metabolomics profile was evaluated. A single-center retrospective cohort study was conducted. Three hundred and sixty-one newborn infants were enrolled into the study, and they were grouped according to their birth weight percentile as small for gestational age (SGA, = 69), appropriate for gestational age (AGA, = 168), and large for gestational age (LGA, = 124) infants. In all infants, amino acid and carnitine/acylcarnitine profiles with liquid chromatography-tandem mass spectrometry (LC-MS/MS) were recorded and compared between groups. LGA infants had higher levels of glutamic acid and lower levels of ornithine, alanine, and glycine ( < 0.05) when compared with AGA infants. SGA infants had higher levels of alanine and glycine levels when compared with AGA and LGA infants. Total carnitine, C0, C2, C4, C5, C10:1, C18:1, C18:2, C14-OH, and C18:2-OH levels were significantly higher and C3 and C6-DC levels were lower in SGA infants ( < 0.05). LGA infants had higher C3 and C5:1 levels and lower C18:2 and C16:1-OH levels ( < 0.05). There were positive correlations between free carnitine and phenylalanine, arginine, methionine, alanine, and glycine levels ( < 0.05). Also, a positive correlation between ponderal index and C3, C5-DC, C14, and C14:1 and a negative correlation between ponderal index and ornithine, alanine, glycine, C16:1-OH, and C18:2 were shown. We demonstrated differences in metabolomics possibly reflecting the energy metabolism in newborn infants with intrauterine growth problems in the early postnatal period. These differences might be the footprints of metabolic disturbances in future adulthood.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110833 | PMC |
| http://dx.doi.org/10.3389/fped.2021.646860 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hydrolyzed Feather Meal in Diet of Yellow Catfish (): Effects on Growth Performance, Flesh Quality, Skin Color, and Intestinal Flora.
Aquac Nutr
August 2025
College of Fisheries, Hunan Agricultural University, Changsha 410128, China.
An 8-week feeding trial was conducted to assess the effects of hydrolyzed feather meal (HFM) as a fish meal replacement on the growth performance, flesh quality, skin color, and intestinal microbiota of yellow catfish (). Five isonitrogen (44% crude protein) and isolipidic (8.5% crude lipid) diets were formulated with varying levels of HFM at 0% (FM, control), 2.
View Article and Find Full Text PDFNovel Visceral Obesity Indicators and Associated Metabolic Fingerprint in Incident Diabetic Retinopathy.
Invest Ophthalmol Vis Sci
September 2025
Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology. Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, People's Republic of China.
Purpose: Evidence on the association between visceral obesity and diabetic retinopathy (DR) remains sparse and debatable. We aimed to use three novel indicators, body roundness index (BRI), lipid accumulation product (LAP), and visceral adiposity index (VAI), to investigate the longitudinal relationship between visceral obesity and DR, and explore the potential metabolic mechanisms.
Methods: In this prospective study based on the UK Biobank (UKB), 14,738 individuals with diabetes free of DR at baseline were included.
Cholesterol Accumulation Caused Oxidative Stress Associated With Impaired Antioxidant Capability and Mitochondrial Function in the Liver of Nile Tilapia.
Aquac Nutr
August 2025
Guangdong Provincial Key Laboratories of Marine Biotechnology, Shantou University, Shantou 515063, China.
In mammals, cholesterol accumulation in tissues often results in health damage, such as oxidative stress. In contrast, the adverse effects of cholesterol accumulation on the physiological health of fish remain largely unexplored. The present study investigated the impacts of cholesterol accumulation on oxidative stress and the potential mechanisms involved in Nile tilapia ().
View Article and Find Full Text PDFHydrophilicity-Driven Modulation of Amyloid-β(1-40) Fibrillation by Engineered Nanomaterials.
ACS Appl Mater Interfaces
September 2025
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, 116024 Dalian, China.
Amyloid-β (Aβ) fibrillation is a spontaneous, thermodynamic process governed by nucleation and elongation. While many studies have explored the ability of engineered nanomaterials (ENMs) to modulate Aβ fibrillation, such as inhibitors, promoters, and dual-modulators, the key physicochemical property of ENMs that determines this behavior remains unclear. In this study, we developed a comprehensive library of ENMs with well-controlled physicochemical properties, including surface charges, morphologies, and hydrophilicity, to systematically investigate their effects on Aβ40 fibrillation.
View Article and Find Full Text PDFTissue and Salivary NMR Metabolomics in Reticular-Type Oral Lichen Planus.
NMR Biomed
October 2025
Dermatology Unit, Department of Surgical, Medical, Dental & Morphological Sciences With Interest Transplant, Oncological & Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Oral lichen planus (OLP) is a chronic T-cell-mediated autoimmune disease, with low potential for malignant transformation. Its etiology remains unclear, necessitating immunohistochemical and molecular-level studies to enhance diagnosis and management. Thirteen patients diagnosed with OLP and 13 healthy controls (HCs) were enrolled from three centers.
View Article and Find Full Text PDF