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Identifying changes in functional connectivity in Attention Deficit Hyperactivity Disorder (ADHD) using functional magnetic resonance imaging (fMRI) can help us understand the neural substrates of this brain disorder. Many studies of ADHD using resting state fMRI (rs-fMRI) data have been conducted in the past decade with either manually crafted features that do not yield satisfactory performance, or automatically learned features that often lack interpretability. In this work, we present a tensor-based approach to identify brain networks and extract features from rs-fMRI data. Results show the identified networks are interpretable and consistent with our current understanding of ADHD conditions. The extracted features are not only predictive of ADHD score but also discriminative for classification of ADHD subjects from typically developed children.
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http://dx.doi.org/10.1109/isbi45749.2020.9098584 | DOI Listing |
J Neuropsychiatry Clin Neurosci
September 2025
Department of Psychiatry and Behavioural Neurosciences, McMaster University and Peter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton, Hamilton, ON.
Objective: The authors examined differences in resting-state functional connectivity (rsFC) in the brain between nontreatment-seeking adults with alcohol use disorder (case group) and recreational drinkers without alcohol use disorder (control group) and explored behavioral and psychological mechanisms underlying these differences.
Methods: This case-control study included 140 adults (N=71 with alcohol use disorder and N=69 demographically matched control individuals) who completed a 9-minute resting-state functional MRI scan. About 45% were men, and the mean±SD age was 32.
J Sleep Res
September 2025
Post-Graduate Program in Medical Sciences: Endocrinology, Federal University of Rio Grande do Sul State, UFRGS, Porto Alegre, Brazil.
This study aimed to estimate the occurrence of excessive daytime sleepiness (EDS) and its associated factors among male road transport workers. A cross-sectional study was conducted with a non-probabilistic sample of 414 drivers recruited at gas stations and parking lots in Formosa and Rio Verde, Goiás, Brazil, in 2024. The presence of EDS was evaluated using the Epworth Sleepiness Scale, and the investigated associated factors included demographic, socioeconomic, behavioural, health and professional characteristics.
View Article and Find Full Text PDFObesity (Silver Spring)
September 2025
Department of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA.
Objective: This secondary analysis was conducted to compare the magnitude of adaptive thermogenesis (AT) following hypocaloric low-carbohydrate (CHO) versus low-fat diets in African American (AA) women.
Methods: Sixty-nine AA women with obesity were randomized to low-CHO or low-fat hypocaloric diets for 10 weeks, followed by a 4-week weight stabilization period (all food provided). At baseline and Week 13, insulin sensitivity (S) was measured by intravenous glucose tolerance test, body composition by bioimpedance analysis, total energy expenditure (EE) (TEE) by doubly labeled water, and resting EE (REE) by indirect calorimetry.
Genome Biol
September 2025
Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang, Hangzhou, 310029, China.
Metagenomic analyses of microbial communities have unveiled a substantial level of interspecies and intraspecies genetic diversity by reconstructing metagenome-assembled genomes (MAGs). The MAG database (MAGdb) boasts an impressive collection of 74 representative research papers, spanning clinical, environmental, and animal categories and comprising 13,702 paired-end run accessions of metagenomic sequencing and 99,672 high quality MAGs with manually curated metadata. MAGdb provides a user-friendly interface that users can browse, search, and download MAGs and their corresponding metadata information.
View Article and Find Full Text PDFJ Med Genet
September 2025
Department of Pediatrics, Danish Epilepsy Center, Dianalund, Denmark
Rare variants in , the gene encoding the GluA3 subunit of amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs), are associated with defects in early brain development. Disease-causing variants are generally categorised as either loss of function (LoF) or gain of function (GoF) that appear to be linked to different symptoms. Here, we reported a de novo variant (N651D) that has mixed LoF and GoF in a female patient with a devastating developmental and epileptic encephalopathy, parkinsonism and cortical malformation.
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