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Highly branched dendritic structures are common in nature and often difficult to quantify and therefore compare. Cranial neurovascular canals, examples of such structures, are osteological correlates for somatosensory systems and have been explored only qualitatively. Adaptations of traditional stream-ordering methods are applied to representative structures derived from computed tomography-scan data. Applying these methods to crocodylian taxa, this clade demonstrates a shared branching pattern and exemplifies the comparative utility of these methods. Additionally, this pattern corresponds with current understanding of crocodylian sensory abilities and behaviors. The method is applicable to many taxa and anatomical structures and provides evidence for morphology-based hypotheses of sensory and physiological evolution.
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http://dx.doi.org/10.1002/jmor.21295 | DOI Listing |
J Neurosci Methods
September 2025
Bioengineering College of Chongqing University, Chongqing University Central Hospital (Chongqing Emergency Medical Center), Chongqing, China; Chongqing Key Laboratory of Emergency Medicine, Chongqing, China. Electronic address:
Background: Current neurovascular unit isolation requires processing brain microvascular endothelial cells (BMECs) and neurons from separate animals, preventing concurrent analysis of neurovascular crosstalk within identical genetic/physiological contexts.
New Methods: We developed an enzymatic digestion/bovine serum albumin density gradient technique that enables the simultaneous isolation of neural tissue and microvascular segments from individual mice. The neural tissue was filtered and centrifuged for primary cortical neuron culture on poly-L-lysine-coated plates.
World Neurosurg
September 2025
Headache and Facial Pain Service, Guy's and St Thomas' NHS Foundation Trust, London, UK; Wolfson SPaRC, Institute of Psychiatry, Psychology & Neuroscience, King's College London. Electronic address:
Objective: This analysis aims to evaluate the sustained effectiveness of trigeminal microvascular decompression (MVD) in patients with medically refractory Short-lasting Unilateral Neuralgiform Headache Attacks (SUNHA) who demonstrate trigeminal neurovascular conflict (NVC) ipsilateral to the painful side.
Methods: This is a retrospective single-centre analysis of prospectively collected data conducted between September 2012 and March 2025 to investigate the efficacy and safety of trigeminal MVD in consecutive refractory chronic SUNHA patients suitable for surgery. All patients underwent a magnetic resonance imaging (MRI) with specific trigeminal sequences before surgery.
Introduction: Neurovascular compression (NVC) often drives trigeminal neuralgia (TGN) pathology. This study examines the incidence, diagnostic accuracy, and role of NVC.
Methods: We conducted a retrospective review of patients ≥18 years with medically refractory TGN who underwent MRI, plus a secondary cohort of medically responsive patients.
Clin Neurol Neurosurg
October 2025
Department of Psychology, Islamic Azad University of Torbat-e Jam, Mashhad, Iran.
Background: Alzheimer's disease (AD) is characterized by a complex interplay between amyloid-β (Aβ) and tau pathologies, with increasing evidence implicating cerebral blood flow (CBF) alterations as a critical, yet underexplored, contributor to disease progression. This study aimed to investigate the associations between regional CBF and cerebrospinal fluid (CSF) biomarkers- Aβ1-42, total tau (T-Tau), and phosphorylated tau (P-Tau181)-across the AD continuum.
Methods: We conducted a cross-sectional analysis using data from 416 participants enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI), including cognitively normal individuals, patients with mild cognitive impairment (MCI), and those with AD.
Headache
August 2025
Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha, People's Republic of China.
Objective: This study aimed to quantify the associations of low-level ambient nitrogen dioxide (NO) and seasonal temperatures with migraine incidence.
Background: Migraine is a highly disabling neurovascular disorder in which attacks are affected by short-term high-level air pollution; however, the associations of long-term low-level air pollution and climate change on migraine incidence are unknown.
Methods: In this prospective cohort study using data from the UK Biobank, 407,792 participants without migraine at baseline were included.