Publications by authors named "Steve Connor"

Objective: This analysis aims to evaluate the sustained effectiveness of trigeminal microvascular decompression (MVD) in patients with medically refractory Short-lasting Unilateral Neuralgiform Headache Attacks (SUNHA) who demonstrate trigeminal neurovascular conflict (NVC) ipsilateral to the painful side.

Methods: This is a retrospective single-centre analysis of prospectively collected data conducted between September 2012 and March 2025 to investigate the efficacy and safety of trigeminal MVD in consecutive refractory chronic SUNHA patients suitable for surgery. All patients underwent a magnetic resonance imaging (MRI) with specific trigeminal sequences before surgery.

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Temporomandibular joint dysfunction (TMD) is a common condition, yet multifactorial in nature. Our understanding of the interplay between clinical symptoms in relation to magnetic resonance imaging (MRI) findings and quality of life is limited. Our primary objective therefore was to identify features of TMD that contribute to anxiety and depression.

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Acute head and neck infections are common in the population and can have serious complications. Prompt diagnosis and treatment are necessary to avoid morbidity and mortality. Imaging is not indicated for uncomplicated acute rhinosinusitis, otomastoiditis, or limited face and neck soft tissue infections (such as tonsillar or odontogenic infections).

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Objective: The primary objective was to determine which of the following angular insertion depth (AID) estimation methods had the strongest correlation with the post-operative AID (AIDpost-op) of a lateral wall (LW) electrode: 1) Escudé formula based on the largest distance from the round window (RW) to the LW (distance A), 2) the elliptic-circular approximation (ECA) method based on both distance A and the perpendicular distance (distance B), 3) a 3D reconstruction method. The secondary objective was to evaluate the impact of using the actual electrode insertion length on the evaluation of the AID estimation methods.

Methods: The study included 45 cochleae implanted with the Advanced Bionics SlimJ electrode, with all 16 active electrode contacts being intracochlear.

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Purpose: A distinct form of cochlear hypoplasia, characterized by the preservation of the first half of the basal turn with hypoplastic and anteriorly displaced upper turns, was historically associated with branchio-oto-renal (BOR) syndrome, but can also occur in other genetic, syndromic and non-syndromic causes of hearing loss. This study aims to describe this phenotype with relative preservation of the basal turn, particularly its first half, in a significant proportion of cochlear hypoplasia cases due to different causes.

Methods: We retrospectively reviewed temporal bone imaging from 125 patients (250 ears) with cochlear malformations from a tertiary pediatric center, focusing on cases where the basal turn was partially or completely preserved.

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Objectives: To compare the presence of internal auditory meatus vascular loops (IVLs) or vestibulocochlear neurovascular contact (CN8-NVC) between unexplained unilateral pulsatile tinnitus (PT) ears and contralateral asymptomatic ears. Furthermore, to investigate whether IVL depth or angulation, or CN8-NVC location is associated with the presence of PT.

Materials And Methods: Single-centre retrospective case-controlled study of patients undergoing three-dimensional T2-weighted MRI for unexplained unilateral PT from January 2012 to July 2021.

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Objectives: To establish how MRI descriptors on standard MRI sequences can be optimally combined to predict idiopathic intracranial hypertension (IIH).

Methods: A retrospective single-institution cross-sectional study evaluated consecutive IIH patients undergoing MRI between 2002 and 2015 and a control group. Six established and 8 exploratory MRI descriptors were evaluated.

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Background: Vestibular schwannoma (VS) management decisions are made within multidisciplinary meetings (MDMs). The improved accuracy of volumetric compared to linear tumor measurements is well-recognized, but current volumetric evaluation methods are too time-intensive. The aim was to determine if the availability of fully automated volumetric tumor measures during MDM preparation resulted in different radiological outcomes compared to a standard approach with linear dimensions, and whether this impacted the clinical management decisions.

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Objective: The goal of this international survey was to understand how diffusion (DWI) and perfusion imaging (PWI) are being applied to clinical head and neck imaging.

Methods And Materials: An online questionnaire focusing on acquisition, clinical indications, analysis, and reporting of qualitative DWI (QlDWI), quantitative DWI (QnDWI) and dynamic contrast-enhanced PWI (DCE-PWI) in the head and neck was circulated to members of the American Society of Head and Neck Radiology (ASHNR) and European Society of Head and Neck Radiology (ESHNR) over a 3-month period. Descriptive statistics and group comparisons were calculated with SPSS® v27.

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Article Synopsis
  • Tinnitus affects about 25% of older adults, with non-pulsatile tinnitus usually lacking structural causes, while pulsatile tinnitus may indicate underlying health issues that can be identified through imaging.
  • A thorough clinical evaluation is essential for determining the appropriate diagnostic strategy and imaging is warranted for unilateral non-pulsatile tinnitus or any pulsatile tinnitus cases.
  • Imaging methods like MRI or CT are used based on the type of tinnitus and any accompanying symptoms, with special attention needed for potential serious conditions in cases of pulsatile tinnitus.
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Objectives: To compare the performance and optimal combination of MRI descriptors used for the diagnosis of Ménière's disease (MD) between a real-IR sequence with "zero-point" endolymph (ZPE), and an optimised real-IR sequence with negative signal endolymph (NSE).

Materials And Methods: This retrospective single-centre cross-sectional study evaluated delayed post-gadolinium ZPE and NSE real-IR MRI in consecutive patients with Ménièriform symptoms (8/2020-10/2023). Two observers assessed 14 MRI descriptors.

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Introduction: Organoids have been successfully used in several areas of cancer research and large living biobanks of patient-derived organoids (PDOs) have been developed from various malignancies. The characteristics of the original tumour tissue such as mutation signatures, phenotype and genetic diversity are well preserved in organoids, thus showing promising results for the use of this model in translational research. In this study, we aim to assess whether we can generate PDOs from head and neck squamous cell carcinoma (HNSCC) samples and whether PDOs can be used to predict treatment sensitivity in HNSCC patients as well as to explore potential biomarkers.

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Purpose: Hypoxia is a major cause of radioresistance in head and neck cancer (HNC), resulting in treatment failure and disease recurrence. F-fluoromisonidazole [F]FMISO PET has been proposed as a means of localising intratumoural hypoxia in HNC so that radiotherapy can be specifically escalated in hypoxic regions. This concept may not be deliverable in routine clinical practice, however, given that [F]FMISO PET is costly, time consuming and difficult to access.

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Background: Intrameatal vascular loops (IVL) entering the internal auditory meatus and neurovascular contact (NVC) with the vestibulocochlear nerve (cranial nerve [CN] VIII) have been proposed to have a relationship with audiovestibular symptoms.

Purpose: This systematic review and meta-analysis aimed to determine whether the presence of IVLs and CN VIII NVC on MRI is associated with tinnitus, sensorineural hearing loss (SNHL), or vertigo and any specific subtypes.

Data Sources: All studies comparing the presence of IVL or CN VIII NVC in ears with these audiovestibular symptoms and controls were identified through MEDLINE, EMBASE, the Web of Science Core Collection, Scopus, and the Cochrane Register of Controlled Trials databases.

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Although non-malignant, middle ear cholesteatoma can result in significant complications due to local bone erosion and infection. The treatment of cholesteatoma is surgical, but residual disease is common and may be clinically occult, particularly when the canal wall is preserved or reconstructive techniques are employed. Imaging plays a pivotal role in the management of patients with middle ear cholesteatoma-aiding clinical diagnosis, identifying complications, planning surgery, and detecting residual disease at follow-up.

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Purpose: To compare the calibre of the cochlear (CN), superior vestibular (SVN) and inferior vestibular (IVN) nerves on magnetic resonance imaging (MRI), both between Ménière's Disease (MD) ears and clinical controls, and between inner ears with and without endolymphatic hydrops (EH) on MRI.

Methods: A retrospective case-control study evaluated patients undergoing MRI for suspected hydropic ear disease from 9/2017 to 8/2022. The CN, SVN, IVN and facial nerve (FN) diameters and cross-sectional areas (CSA) were measured on T2-weighted sequences whilst EH was evaluated on delayed post-gadolinium MRI.

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Article Synopsis
  • Automatic segmentation of vestibular schwannoma from clinical MRI can enhance clinical efficiency and treatment decisions.
  • A multi-center routine clinical dataset of 160 patients with annotated MRI scans was created, demonstrating the feasibility and accuracy of automatic segmentation in diverse MRI datasets.
  • The developed deep learning models showed impressive performance, with average Dice similarity coefficients comparable to radiologists, indicating strong reliability and accuracy in segmenting vestibular schwannomas across various imaging modalities.
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Objectives: To evaluate the diagnostic performance and reliability of MRI descriptors used for the detection of Ménière's disease (MD) on delayed post-gadolinium MRI. To determine which combination of descriptors should be optimally applied and whether analysis of the vestibular aqueduct (VA) contributes to the diagnosis.

Materials And Methods: This retrospective single centre case-control study evaluated delayed post-gadolinium MRI of patients with Ménièriform symptoms examined consecutively between Dec 2017 and March 2023.

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Scalar translocation is a severe form of intra-cochlear trauma during cochlear implant (CI) electrode insertion. This study explored the hypothesis that the dimensions of the cochlear basal turn and orientation of its inferior segment relative to surgically relevant anatomical structures influence the scalar translocation rates of a pre-curved CI electrode. In a cohort of 40 patients implanted with the Advanced Bionics Mid-Scala electrode array, the scalar translocation group (40%) had a significantly smaller mean distance A of the cochlear basal turn (p < 0.

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Objectives: To evaluate ancillary MRI features which may aid the identification of lateral temporal bone cephaloceles (LTBCs).

Methods: A retrospective cohort study analysed patients with MRI evidence of surgically confirmed spontaneous LTBCs as defined by intracranial contents traversing the tegmen tympani or mastoideum. Cases were identified from radiology and surgical databases.

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Cutaneous lesions are derived from the epidermis, dermis and cutaneous appendages. Whilst imaging may occasionally be performed to evaluate such lesions, they may be undiagnosed and demonstrated for the first time on head and neck imaging studies. Although usually amenable to clinical examination and biopsy, CT or MRI studies may also demonstrate characteristic imaging features which aid the radiological differential diagnosis.

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Objectives: Delayed post-gadolinium magnetic resonance imaging (MRI) detects changes of endolymphatic hydrops (EH) within the inner ear in Meniere's disease (MD). A systematic review with meta-analysis was conducted to summarise the diagnostic performance of MRI descriptors across the range of MD clinical classifications.

Materials And Methods: Case-controlled studies documenting the diagnostic performance of MRI descriptors in distinguishing MD ears from asymptomatic ears or ears with other audio-vestibular conditions were identified (MEDLINE, EMBASE, Web of Science, Scopus databases: updated 17/2/2022).

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Article Synopsis
  • Craniopharyngiomas are typically benign tumors located in the brain's suprasellar region, but this case involves a rare and aggressive form that spread to the spine.
  • A 67-year-old woman with a history of breast cancer experienced severe neurological symptoms, and MRI scans showed a rapidly growing tumor that required surgical intervention and further analysis.
  • Despite surgery, the patient underwent palliative care and passed away four months later, underscoring the importance of accurate histological diagnosis for effective treatment of such complex cases.
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