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Fluorescent probes in the NIR-II region provide high bioimaging quality. Optimizing the probe structure to achieve NIR-II imaging is ongoing, but remains challenging. Herein, increasing the electron withdrawing ability of the substituent in monochlorinated BODIPY greatly adjusted the emission wavelength from the NIR-I to NIR-II region, giving an efficient design strategy of NIR-II probes.
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http://dx.doi.org/10.1039/d0tb02120b | DOI Listing |
Mater Horiz
September 2025
Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China.
NIR-II probes show great potential for fluorescence imaging (FLI) and therapeutics, where the molar extinction coefficient (MEC), a pivotal optical parameter, governs their imaging quality and therapeutic efficacy. Nevertheless, engineering NIR-II probes with ultrahigh MEC remains a formidable challenge, limiting their biomedical applications. In this work, we designed a superior NIR-II D-π-A-π-D probe, SCU-SX-T, which features an S-xanthene core as the conjugate acceptor, a diphenylamine (DPA) rotor, and π-bridge that induces bathochromic shifts in absorption/emission spectra while enhancing molecular rigidity and planarity.
View Article and Find Full Text PDFChem Sci
August 2025
Department of Chemistry and Chemical Biology, Rutgers University Piscataway NJ 08854 USA
Near-infrared (NIR) luminescent materials are pivotal for advanced optoelectronic and biomedical applications, yet attaining efficient emission in the NIR-II region (950-1400 nm) remains challenging. Here, we introduce a ligand cationization strategy for designing copper(i) iodide-organic hybrid materials that emit in the NIR-II region (920-1120 nm) with PLQYs up to 8.58%.
View Article and Find Full Text PDFInorg Chem
August 2025
Beijing Key Laboratory for Optical Materials and Photonic Devices, Department of Chemistry, Capital Normal University, Beijing 100048, China.
Crystalline coordination polymers (CCPs) have emerged as promising platforms for photothermal conversion due to their structural tunability. However, the development of high-performance CCPs is often limited by the high cost of photoactive ligands. In this study, we report a low-cost, scalable approach to synthesize three CCPs─-, -, and -─via a solvothermal method using the inexpensive industrial precursor tetrafluoroterephthalonitrile, which is converted in situ into a tetraoxolene ligand.
View Article and Find Full Text PDFNeurosci Bull
August 2025
School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.
Cerebral edema is characterized by fluid accumulation, and the glymphatic system (GS) plays a pivotal role in regulating fluid transport. Using the Tenecteplase system, magnesium salt of salvianolic acid B/ginsenoside Rg1 (SalB/Rg1) was injected intravenously into mice 4.5 h after middle cerebral artery occlusion and once every 24 h for the following 72 h.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
August 2025
State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, 210023, China.
The development of activatable optical probes has proved to be a promising approach to improve the accuracy of phototheranostics. However, most such probes are usually responsive to single pathological factor and visible-near-infrared-I light upon activation, which restricts the theranostic specificity and tissue penetration depth, respectively. Herein, we develop a nitric oxide (NO) and acidity dual-stimuli responsive semiconducting polymer nanoprobe for activatable near-infrared-II (NIR-II) photoacoustic imaging (PAI) and photothermal therapy (PTT).
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