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Grape (Vitis vinifera L. var. Albariño) and mulberry (Morus nigra L.) seeds pomace were characterized in terms of tocopherols, organic acids, phenolic compounds and bioactive properties. Higher contents of tocopherols (28 ± 1 mg/100 g fw) were obtained in mulberry, whilst grape seeds were richer in organic acids (79 ± 4 mg/100 g fw). The phenolic analysis of hydroethanolic extracts characterised grape seeds by catechin oligomers (36.0 ± 0.3 mg/g) and mulberry seeds by ellagic acid derivatives (3.14 ± 0.02 mg/g). Both exhibited high antimicrobial activity against multiresistant Staphylococcus aureus MIC = 5 mg/mL) and no cytotoxicity against carcinogenic and non-tumour primary liver (PLP) cells. Mulberry seeds revealed the strongest inhibition (p < 0.05) against thiobarbituric reactive substances (IC = 23 ± 2 µg/mL) and oxidative haemolysis (IC at 60 min = 46.0 ± 0.8 µg/mL). Both seed by-products could be exploited for the developing of antioxidant-rich ingredients with health benefits for industrial application.
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http://dx.doi.org/10.1016/j.foodchem.2020.127998 | DOI Listing |
Med Oncol
September 2025
Department of Biotechnology, Institute of Engineering and Management, University of Engineering and Management, Kolkata, Kolkata, India.
Oligomeric proanthocyanidins (OPCs), condensed tannins found plentiful in grape seeds and berries, have higher bioavailability and therapeutic benefits due to their low degree of polymerization. Recent evidence places OPCs as effective modulators of cancer stem cell (CSC) plasticity and tumor growth. Mechanistically, OPCs orchestrate multi-pathway inhibition by destabilizing Wnt/β-catenin, Notch, PI3K/Akt/mTOR, JAK/STAT3, and Hedgehog pathways, triggering β-catenin degradation, silencing stemness regulators (OCT4, NANOG, SOX2), and stimulating tumor-suppressive microRNAs (miR-200, miR-34a).
View Article and Find Full Text PDFPlants (Basel)
August 2025
Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA), Consejo Superior de Investigaciones Científicas (CSIC), Cordel de Merinas, 40, 37008 Salamanca, Spain.
Seeds of different cultivars ( subsp. ) have an interesting diversity of shapes, ranging from the small seeds of high solidity and low aspect ratio in some species of and subsp. to other morphological types with elongated stalks, characteristic of the more recent cultivars, suggesting a transition with alterations in seed shape associated with groups of cultivars.
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August 2025
College of Enology, Northwest A&F University, Yangling 712100, China.
With the development of people's diets and working patterns, obesity is an increasingly serious health threat faced globally. Grape pomace is an important by-product generated during the wine production process which is rich in polyphenols. Polyphenols show promising potential in anti-inflammatory, antioxidant, and metabolic regulatory applications.
View Article and Find Full Text PDFFood Chem
August 2025
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China; Jiangsu Key Laboratory of Medicinal Substance and Utilization of Fresh Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:
This study developed functional soybean protein isolate (SPI)-based films incorporated with plant-derived oleosomes (mustard, grape, and chili seeds) and systematically evaluated their physicochemical properties, antioxidant and antimicrobial activities, and food preservation efficacy. Films were fabricated by integrating oleosomes into SPI matrices, followed by solvent casting. Physicochemical characterization revealed that films with grape seed oleosomes provided the most significant improvements compared to control SPI films: reduced transparency (56 %), water vapor permeability (11 %), and lipid peroxidation (43 % lower peroxide value); increased hydrophobicity (contact angle +20 %) and flexibility (elongation at break +16 %).
View Article and Find Full Text PDFFood Chem
November 2025
Department of Agricultural Sciences, University of Naples Federico II, Piazza Carlo di Borbone, 1, 80055 Portici (NA), Italy.
Pedoenvironmental factors play a key role in winegrape quality. In five vineyards, elemental profiles (B, Ca, Cu, Fe, K, Li, Mg, Mn, Na, Ni, P, S, Si, Sr, Zn) of grape seeds, pulp, skin, and wine-like-juice (WLJ) (except S), and soil element content (NHOAc extraction) were analyzed by Inductively-Coupled-Plasma Optical-Emission-Spectrometry. ANOVA showed homogeneity of grape and soil composition across vineyards.
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