Is increasing pretreatment HIV drug resistance a real menace or minor detail? - Authors' reply.

Lancet HIV

Center for Global Infectious Diseases Research, Seattle Children's Research Institute, Seattle, WA 98109, USA; Department of Laboratory Medicine and Department of Paediatrics, University of Washington, Seattle, WA, USA. Electronic address:

Published: May 2020


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2352-3018(20)30049-7DOI Listing

Publication Analysis

Top Keywords

increasing pretreatment
4
pretreatment hiv
4
hiv drug
4
drug resistance
4
resistance real
4
real menace
4
menace minor
4
minor detail?
4
detail? authors'
4
authors' reply
4

Similar Publications

OsPIL1 Differentially Modulates Rice Blast Resistance Through Integrating Light or Darkness During Magnaporthe oryzae Infection.

Plant Cell Environ

September 2025

State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, College of Plant Protection, Yunnan Agricultural University, Kunming, China.

Light and darkness are critical environmental factors that regulate plant immune responses. OsPIL1, a phytochrome-interacting factor-like protein, has been implicated in rice immunity against Magnaporthe oryzae, although its underlying mechanism remains unclear. This study aimed to dissect how OsPIL1 integrates light or darkness to modulate rice immunity.

View Article and Find Full Text PDF

Background: Hyperthermia (HT), while a cancer treatment approach, isn't always effective alone. Therefore, identifying hyperthermia enhancers is crucial. We demonstrated that Mito-TEMPO ([2-[(1-Hydroxy-2,2,6,6-tetramethylpiperidin-4-yl) amino]-2-oxoethyl]-triphenylphosphanium, MT) acts as a potent thermosensitizer, promoting cell death in human cervical cancer (HeLa) cells.

View Article and Find Full Text PDF

In response to the challenges of nutrient limitations and low efficiency in synthesizing artificial humic acid (AHA) during the resource utilization of agricultural wastes, this study innovatively developed a process that integrates biogas slurry (BS) impregnation pretreatment with hydrothermal humification (HTH). Using steam-exploded corn straw (SES) as the raw material, the impregnation parameters were optimized (40 °C, liquid-to-solid ratio of 15:1, 18 h, 3 cycles), achieving an AHA yield of 40.61 %, which was over 15 % higher than that of the untreated group.

View Article and Find Full Text PDF

Levofloxacin-induced seizure susceptibility involves both enhanced glutamatergic and impaired GABAergic synaptic function.

Brain Res

September 2025

Department of Geriatric Rehabilitation, Clinical Research Center for Geriatric Disorders of Guangxi Zhuang Autonomous Region, Guangxi, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, No 85 Hedi Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China. Electronic address: 13657813091@163

Levofloxacin (LVFX)-associated seizures are thought to arise from disrupted excitatory-inhibitory balance, but the underlying synaptic mechanisms remain unclear. This study investigated how LVFX alters both glutamatergic and GABAergic transmission to promote neuronal hyperexcitability. We combined in vitro and in vivo approaches using primary cortical neurons treated with LVFX and adult rats administered LVFX.

View Article and Find Full Text PDF

Response Characteristics of Barrel Cortical Neurons in Layers IV/V of Juvenile Rats with Autism-Like Traits after Tactile Stimulation.

Physiol Behav

September 2025

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; Cognitive Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

The barrel cortex is a specialized region of the primary somatosensory cortex that processes tactile information from whiskers. This study investigates how tactile stimulation (TS) affects excitatory receptive fields and surrounds suppression in barrel cortex neurons of male and female autistic-like rats, using various whisker displacement protocols. The animals were categorized into control, Valproic acid pre-treated (Val), and Val-TS treatment groups.

View Article and Find Full Text PDF