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Purpose: To present and demonstrate the accuracy of a modified formalism for electron beam reference dosimetry using updated Monte Carlo calculated beam quality conversion factors.
Methods: The proposed, simplified formalism allows the use of cylindrical ionization chambers in all electron beams (even those with low beam energies) and does not require a measured gradient correction factor. Data from a previous publication are used for beam quality conversion factors. The formalism is tested and compared to the present formalism in the AAPM TG-51 protocol with measurements made in Elekta Precise electron beams with energies between 4 MeV and 22 MeV and with fields shaped with a 10 × 10 cm clinical applicator as well as a 20 × 20 cm clinical applicator for the 18 MeV and 22 MeV beams. A set of six ionization chambers are used for measurements (two cylindical reference-class chambers, two scanning-type chambers and two parallel-plate chambers). Dose per monitor unit is derived using the data and formalism provided in the TG-51 protocol and with the proposed formalism and data and compared to that obtained using ionization chambers calibrated directly against primary standards for absorbed dose in electron beams.
Results: The standard deviation of results using different chambers when TG-51 is followed strictly is on the order of 0.4% when parallel-plate chambers are cross-calibrated against cylindrical chambers. However, if parallel-plate chambers are directly calibrated in a cobalt-60 beam, the difference between results for these chambers is up to 2.2%. Using the proposed formalism and either directly calibrated or cross-calibrated parallel-plate chambers gives a standard deviation using different chambers of 0.4%. The difference between results that use TG-51 and the primary standard measurements are on the order of 0.6% with a maximum difference in the 4 MeV beam of 2.8%. Comparing the results obtained with the proposed formalism and the primary standard measurements are on the order of 0.4% with a maximum difference of 1.0% in the 4 MeV beam.
Conclusions: The proposed formalism and the use of updated data for beam quality conversion factors improves the consistency of results obtained with different chamber types and improves the accuracy of reference dosimetry measurements. Moreover, it is simpler than the present formalism and will be straightforward to implement clinically.
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http://dx.doi.org/10.1002/mp.14048 | DOI Listing |
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July 2025
Department of Environmental Science, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.
Hydraulic shear has been widely accepted as one of the essential factors modulating phytoplankton growth. Previous experimental studies of algal growth have been conducted at the macroscopic level, and direct observation at the cell scale has been lacking. In this study, an algal-cell dynamic continuous observation platform (ACDCOP) is proposed with a parallel-plate flow chamber (PPFC) to capture cellular growth images which are then used as input to a computer vision algorithm featuring a pre-trained backpropagation neural network to quantitatively evaluate the volumes and volumetric growth rates of individual cells.
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July 2025
Biomedical Engineering Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA.
The endothelial glycocalyx (GCX) plays a crucial role in vascular health and integrity and influences many biochemical activities through mechanotransduction, in which heparan sulfate (HS) plays a major role. Endothelin-1 (ET-1) is a potent vasoregulator that binds to the endothelin B receptor (ETB) on endothelial cells (ECs), stimulating vasodilation, and to the endothelin A receptor on smooth muscle cells, stimulating vasoconstriction. While the shear stress (SS) dependence of ET-1 and HS is well documented, there is limited research documenting the SS dependence of the ETB.
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July 2025
Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
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July 2025
Department of Radiation Oncology Physics & Technology, Cancer Hospital of Shandong First Medical University, Jinan, People's Republic of China.
To experimentally determine beam quality correction factors () for six cylindrical and four parallel-plate ionization chambers (ICs) in both spread-out Bragg peak (SOBP) and single-layer proton beam configurations.Water calorimetry was implemented to establish absorbed dose to water () at 10 g cmdepth for SOBP and single-layer proton beams. IC measurements were performed under identical geometrical conditions as calorimetric measurements, with the exception of water temperature control in the phantom.
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November 2025
Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN), Comissão Nacional de Energia Nuclear, Av. Prof. Lineu Prestes 2242, 05508-000, São Paulo, SP, Brazil.
The aim of this work was to verify the possibility of the application of a special parallel-plate ionization chamber, developed at the Calibration Laboratory (IPEN), for mammography dosimetry. The homemade chamber has a polymethyl methacrylate body, 10 cm of sensitive length, and a sensitive volume of 3.2 cm.
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