Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Negative pressure therapy plays an important role in the healing process of different types of wounds.
Aim Of The Study: this study aimed to compare between modified and traditional method of vacuum wound closure for chronic wounds.
Subjects: Thirty participants with chronic ulcers completed the study, their ages ranged from 47 to 65 years, from Benha city, divided randomly into two groups, it was carried out from December 2017 to March 2019.
Methods: The first group treated by the traditional method of vacuum assisted wound closure for 8 weeks; dressing was changed 3 times weekly, at 125 mmHg. The mode of 2 min off and 5 min on was used. The second group treated by the modified method by switching off the device at the fifth week and applying traditional dressing for one week then ended by three weeks of vacuum wound closure. Assessment was performed before and after the study. Student t-test was used for analysis.
Result: Paired t-test showed a significant improvement in wound surface area as well as volume for pre and post treatment in each group (p < 0.05). On the other hand independent t-test revealed a non-significant difference between the two groups pre as well as post treatment (p > 0.05).
Conclusion: There is no significant difference between the two programs on healing of chronic ulcers.
Clinical Trial Registration No: NCT03701152 - at Clinicaltrials.gov.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jtv.2019.10.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Functional analysis of secreted tissue inhibitor of metalloproteinases-1 from adult human neural stem cells (ahNSCs) for regeneration and neuroprotection.
BMB Rep
September 2025
Medical Innovation Technology Inc. (MEDINNO Inc.), Seoul 08517; Department of Anatomy & Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419; Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351; Department of Health
The adult human neural stem cell (ahNSC)-conditioned medium (CM) contains various secreted factors that promote tissue repair and neuroprotection. This study aimed to identify the key secreted proteins in ahNSC-CM and investigate the role of tissue inhibitor of metalloproteinases-1 (TIMP-1) in wound healing, angiogenesis, and neuroprotection against oxygenglucose deprivation. Cytokine array and liquid chromatography- tandem mass spectrometry analysis of ahNSC-CM revealed that monocyte chemoattractant protein-1 (MCP-1) and TIMP-1 were highly abundant.
View Article and Find Full Text PDFWound Healing Properties of Nymphaea alba (Nymphaeaceae) Flower Extract: Evidence from In Vivo, In Vitro, and In Silico Network Analysis.
Curr Comput Aided Drug Des
September 2025
Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park-II, Institutional Area, Greater Noida, U.P, 201306, India.
Introduction: The white water lily (Nymphaea alba) is a traditional medicinal plant recognized for its diverse array of bioactive properties. However, its potential in wound healing remains largely unexplored. This study aimed to evaluate the phytochemical profile, cytotoxicity, and wound healing efficacy of Nymphaea alba flower extract (NAFE) using both in vitro and in vivo models, as well as computational network analysis.
View Article and Find Full Text PDFTick extracellular vesicles alter epidermal keratinocyte function.
J Invest Dermatol
September 2025
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:
Wound healing has been extensively studied through the lens of inflammatory disorders and cancer, but limited attention has been given to hematophagy and arthropod-borne diseases. Hematophagous ectoparasites, including ticks, subvert the wound healing response to maintain prolonged attachment and facilitate blood-feeding. Here, we unveil a strategy by which extracellular vesicles (EVs) ensure blood-feeding and arthropod survival in three medically relevant tick species.
View Article and Find Full Text PDFMussel-inspired adhesive macromolecule modified zinc oxide nanoparticles incorporated into polyethylene glycol hydrogels for enhancing infected wound healing.
Colloids Surf B Biointerfaces
August 2025
Department of Orthopedics, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330006, China. Electronic address:
Infected wounds remain a major clinical challenge due to bacterial invasion, which disrupts the natural healing cascade through excessive reactive oxygen species (ROS) generation, severe vascular damage, and persistent inflammation. Inspired by the catechol-rich adhesive domains of mussel foot proteins, we developed an extracellular matrix (ECM)-mimetic polyethylene glycol (PEG) hydrogel incorporating polydopamine (PDA)-functionalized zinc oxide nanoparticles (ZnONPs) for infected wound therapy. The amino acid-functionalized PEG hydrogel reproduces ECM-like properties to facilitate cell migration and efficient exudate management; however, its lack of intrinsic antimicrobial activity limits therapeutic efficacy.
View Article and Find Full Text PDFMarine organism-inspired tough and adhesive patch based on thermosensitive quaternized chitin for tissue sealing/repair and hemostasis.
Carbohydr Polym
November 2025
Key Laboratory of Biomedical Polymers, Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China. Electronic address:
Tissue adhesives have emerged as a promising alternative to conventional sutures and staplers in the management of hemostasis, tissue defect sealing, and wound repair. However, the efficacy of current bio-adhesives in clinical practice is compromised by the limitations, including poor wet adhesion, inadequate mechanical strength, vulnerability to gastrointestinal fluids, and insufficient hemostatic performance. Herein, a marine organism-inspired tough and adhesive patch (MOTAP) was developed to address these challenges.
View Article and Find Full Text PDF