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Near infrared (NIR) spectroscopy is a well-established technique that is widely employed in agriculture, chemometrics, and pharmaceutical engineering. Recently, the technique has shown potential in clinical orthopaedic applications, for example, assisting in the diagnosis of various knee-related diseases (e.g., osteoarthritis) and their pathologies. NIR spectroscopy (NIRS) could be especially useful for determining the integrity and condition of articular cartilage, as the current arthroscopic diagnostics is subjective and unreliable. In this work, we present an extensive dataset of NIRS measurements for evaluating the condition, mechanical properties, structure, and composition of equine articular cartilage. The dataset contains NIRS measurements from 869 different locations across the articular surfaces of five equine fetlock joints. A comprehensive library of reference values for each measurement location is also provided, including results from a mechanical indentation testing, digital densitometry imaging, polarized light microscopy, and Fourier transform infrared spectroscopy. The published data can either be used as a model of human cartilage or to advance equine veterinary research.
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http://dx.doi.org/10.1038/s41597-019-0170-y | DOI Listing |
Phys Chem Chem Phys
September 2025
The Extreme Light Infrastructure ERIC, ELI Beamlines Facility, Za Radnicí 835, Dolní Břežany, Czech Republic.
The significance of carotenoids in biological systems cannot be overstated. Their functionality largely arises from unique excited-state dynamics, where photon absorption promotes the molecule to the optically allowed 1B+u state (conventionally S), which rapidly decays to the optically forbidden 2A-g state (S). While the vibrational signature of the S state is well established, that of the initial S state has remained elusive.
View Article and Find Full Text PDFStroke
September 2025
Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China (H.Z., K.H., Q.G.).
Background: Poststroke cognitive impairment (PSCI) affects 30% to 50% of stroke survivors, severely impacting functional outcomes and quality of life. This study uses functional near-infrared spectroscopy (fNIRS) to assess task-evoked brain activation and its potential for stratifying the severity in patients with PSCI.
Method: A cross-sectional study was conducted at Nanchong Central Hospital between June 2023 and April 2024.
Int J Pharm X
June 2025
Medical School, Southeast University, Nanjing 210009, China.
This study aimed to create multifunctional nanoparticles (NPs), specifically AS1411@MPDA-Len-Cy5.5 (AMLC), for the purpose of developing effective strategies for treating hepatocellular carcinoma (HCC) through targeted therapy and photothermal therapy (PTT). The study involved synthesizing mesoporous polydopamine (MPDA)-NPs, loading lenvatinib (Len) and Cy5.
View Article and Find Full Text PDFInt J Sports Physiol Perform
September 2025
Department of Physical Education and Sport Sciences, National Taiwan Normal University, Taipei, Taiwan.
Purpose: This study explored the acute physiological effects of different eccentric tempos, explosive speed (EXP), volitional speed, and 4-second tempo during 5 sets of velocity-based squat training.
Methods: Twelve healthy males performed parallel squats under 3 eccentric conditions using a randomized crossover design. Each session included 5 sets at a relative load, initiated with a concentric mean velocity of 0.
Int J Sports Physiol Perform
September 2025
Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA.
Purpose: To assess the association between skeletal-muscle endurance performance and mitochondrial oxidative capacity of the hamstrings as respectively measured by biomechanical and physiological standards.
Methods: Nineteen (12 men and 7 women) healthy, young, recreationally active participants enrolled in our study. Participant characteristics comprised a mean and SD age of 21.