Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Objectives: We examined whether a home-based, adaptive cognitive training (CT) program would lead to cognitive performance changes on a neuropsychological test battery in cognitively normal older adults.

Method: Sixty-eight older adults (age = 70.0, SD = 3.74) were randomly assigned to either CT or an active control group (AC, casual computer games). Participants were instructed to train on their assigned programs for 42 min per day, 5 days per week, over 10 weeks (35 hr of total program usage). Participants completed tests of processing speed, working memory, and executive control before and after 10 weeks of training.

Results: Training groups did not differ in performance before training. After training, CT participants out-performed AC participants in the overall cognitive composite score, driven by processing speed and working memory domains.

Discussion: Our results show that a limited dose of home-based CT can drive cognitive improvements as measured with neuropsychological test battery, suggesting potential cognitive health maintenance implications for cognitively normal older adults.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265807PMC
http://dx.doi.org/10.1093/geronb/gbz073DOI Listing

Publication Analysis

Top Keywords

cognitively normal
12
normal older
12
older adults
12
home-based adaptive
8
adaptive cognitive
8
cognitive training
8
neuropsychological test
8
test battery
8
processing speed
8
speed working
8

Similar Publications

Maturational Changes in Action-Effect Integration Processes Are Reflected by Changes in the Directed Cortical Network Communication.

Hum Brain Mapp

September 2025

Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany.

Acting intentionally is a major aspect of human cognitive development and depends on the ability to link actions with their consequences. Action-effect binding (AEB) is a fundamental mechanism enabling this. While AEB has been well-characterized in adults, its neurophysiological underpinnings during adolescence remain unclear.

View Article and Find Full Text PDF

Deletion of the SHORT Syndrome Gene Prkce Results in Brain Atrophy and Cognitive and Motor Behavior Deficits in Mice.

Neurosci Bull

September 2025

Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 311121, China.

The neurological manifestations of SHORT syndrome include intrauterine growth restriction, microcephaly, intellectual disability, hearing loss, and speech delay. SHORT syndrome is generally believed to be caused by PIK3R1 gene mutations and impaired PI3K-AKT activation. Recently, a clinical case report described a SHORT syndrome with a novel mutant in PRKCE gene encoding protein kinase Cε (PKCε).

View Article and Find Full Text PDF

Anatomical connectivity development constrains medial-lateral topography in the dorsal prefrontal cortex.

Sci Bull (Beijing)

August 2025

Beijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Xiaoxiang Institute for Brain Health and Yongzhou Central

View Article and Find Full Text PDF

Exploring the Effect of Negative Mood on Working Memory Subprocesses: An Event-Related Potential Study.

Biol Psychol

September 2025

Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, 610066, China. Electronic address:

Working memory (WM) regulates information flow through gate mechanisms, consisting of four subprocesses: gate opening, gate closing, updating, and substitution. However, their neural mechanisms remain underexplored. While emotion-cognition interactions are well studied, the effects of negative mood on these subprocesses are unclear.

View Article and Find Full Text PDF

Synergistic stress-relieving and cognitive-enhancing effects of walnut peptide and theanine in human brain organoid and mouse stress models.

Phytomedicine

August 2025

Laboratory of Neurological Disease Modeling and Translational Research, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:

Background: Stress is a prevalent mental health concern that often emerges in late adolescence or early adulthood. Since 2007, the Food and Drug Administration (FDA) has not approved any novel anxiolytic pharmaceuticals, leading to increased interest in nutritional supplements as alternative therapies for stress management.

Purpose: Building on our previous study, this work aims to investigate the synergistic effects of Theanine (Th) and Walnut Peptide (WP) on stress mitigation and cognitive enhancement.

View Article and Find Full Text PDF