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Objectives: We examined whether a home-based, adaptive cognitive training (CT) program would lead to cognitive performance changes on a neuropsychological test battery in cognitively normal older adults.
Method: Sixty-eight older adults (age = 70.0, SD = 3.74) were randomly assigned to either CT or an active control group (AC, casual computer games). Participants were instructed to train on their assigned programs for 42 min per day, 5 days per week, over 10 weeks (35 hr of total program usage). Participants completed tests of processing speed, working memory, and executive control before and after 10 weeks of training.
Results: Training groups did not differ in performance before training. After training, CT participants out-performed AC participants in the overall cognitive composite score, driven by processing speed and working memory domains.
Discussion: Our results show that a limited dose of home-based CT can drive cognitive improvements as measured with neuropsychological test battery, suggesting potential cognitive health maintenance implications for cognitively normal older adults.
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http://dx.doi.org/10.1093/geronb/gbz073 | DOI Listing |
Hum Brain Mapp
September 2025
Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany.
Acting intentionally is a major aspect of human cognitive development and depends on the ability to link actions with their consequences. Action-effect binding (AEB) is a fundamental mechanism enabling this. While AEB has been well-characterized in adults, its neurophysiological underpinnings during adolescence remain unclear.
View Article and Find Full Text PDFNeurosci Bull
September 2025
Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
The neurological manifestations of SHORT syndrome include intrauterine growth restriction, microcephaly, intellectual disability, hearing loss, and speech delay. SHORT syndrome is generally believed to be caused by PIK3R1 gene mutations and impaired PI3K-AKT activation. Recently, a clinical case report described a SHORT syndrome with a novel mutant in PRKCE gene encoding protein kinase Cε (PKCε).
View Article and Find Full Text PDFSci Bull (Beijing)
August 2025
Beijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Xiaoxiang Institute for Brain Health and Yongzhou Central
Biol Psychol
September 2025
Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, 610066, China. Electronic address:
Working memory (WM) regulates information flow through gate mechanisms, consisting of four subprocesses: gate opening, gate closing, updating, and substitution. However, their neural mechanisms remain underexplored. While emotion-cognition interactions are well studied, the effects of negative mood on these subprocesses are unclear.
View Article and Find Full Text PDFPhytomedicine
August 2025
Laboratory of Neurological Disease Modeling and Translational Research, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:
Background: Stress is a prevalent mental health concern that often emerges in late adolescence or early adulthood. Since 2007, the Food and Drug Administration (FDA) has not approved any novel anxiolytic pharmaceuticals, leading to increased interest in nutritional supplements as alternative therapies for stress management.
Purpose: Building on our previous study, this work aims to investigate the synergistic effects of Theanine (Th) and Walnut Peptide (WP) on stress mitigation and cognitive enhancement.