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Metal ions play a critical role in human health and abnormal levels are closely related to various diseases. Therefore, the detection of metal ions with high selectivity, sensitivity and accuracy is particularly important. This article highlights and comments on the coordination-induced structural changes of DNA-based optical, electrochemical and optical-electrochemical-combined sensors for metal ions detection. Challenges and potential solutions of DNA-based sensors for the simultaneous detection of multiple metal ions are also discussed for further development and exploitation.
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http://dx.doi.org/10.1039/c8dt04733b | DOI Listing |
Chembiochem
September 2025
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich str. 5/2, 220084, Minsk, Belarus.
The terminal deoxynucleotidyl transferase is a unique polymerase that incorporates nucleotides at the 3'-terminus of single-stranded DNA primers in a template-independent manner. This biological function propels the development of numerous biomedical and bioengineering applications. However, the extensive use of TdT is constrained by its low expression levels in E.
View Article and Find Full Text PDFChemistry
September 2025
Department of Chemistry, Birla Institute of Technology and Science-Pilani, K K Birla Goa Campus, Zuarinagar, Goa, 403726, India.
This study investigates the unique syneresis (self-shrinking) behavior of N-Terminally Fmoc-protected amino acid, Fmoc-hPhe-OH (Fmoc-homo-L-phenylalanine, abbreviated in this work as hF)-based hydrogel, and its potential in environmental remediation applications. Fmoc-hPhe-OH (hF) forms a hydrogel in 50 mM phosphate buffer (PB) of pH 7.4.
View Article and Find Full Text PDFAdv Healthc Mater
September 2025
Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, 300131, China.
Periprosthetic joint infection (PJI) represents a serious complication following joint arthroplasty, and it often results in implant failure, prolonged morbidity, and additional healthcare burdens. Current clinical strategies for PJI treatment face obstacles, including antibiotic resistance, high recurrence rate, and compromised bone repair. To address these challenges, a novel nanozyme-based coordination compound designated as W-GA-Van@Zn is developed.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Department of Material Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Nanoionic devices, crucial for neuromorphic computing and ionically enabled functional actuators, are often kinetically limited. In bilayer configurations, experimentally deconvoluting ion transport within individual layers from the kinetics of transfer across solid-solid interfaces, however, remains a challenge, hindering rational device optimization. Here, we extend the dynamic current-voltage (-) technique to a PrCeO/LaCeCuO (PCO/LCCO) bilayer system, enabling the isolation and quantification of distinct ion transport processes.
View Article and Find Full Text PDFLuminescence
September 2025
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
A triphenyl-imidazole end-capped donor-acceptor type potential molecular probe 3 has been designed and synthesized. Probe 3 upon interaction with different classes of metal ions/anions and NPPs displayed high selectivity with CN anion (LOD = 20.42 nM) through fluorescence "turn-Off" response and a naked-eye sensitive visible color change.
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