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The objective was to evaluate the fracture resistance properties of maxillary incisors with flared canals restored with computer aided design and computer aided manufacture (CAD/CAM) integrated glass fiber post-and-core. Thirty prepared flared root canals were selected in vitro and restored with CAD/CAM integrated fiber post-and-core (Group A), prefabricated fiber posts (Group B), and cast gold alloy (Group C), respectively. After submitted to fatigue loading, each specimen was subjected to a static loading until fracture. Analysis of variance (ANOVA) tests were used to determine statistical differences. The mean fracture strengths of Groups A and C were significantly higher than those of Group B, whereas no differences were observed between Groups A and C. In addition, reparable fracture modes were mostly observed in Group A while irreparable and catastrophic fractures were mostly found in Groups B and C. These results demonstrate that, in comparison to traditional treatments, CAD/CAM integrated glass fiber post-and-core restoration significantly enhances the fracture resistance of flared root canals.
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http://dx.doi.org/10.4012/dmj.2017-394 | DOI Listing |
Int J Oral Implantol (Berl)
September 2025
Purpose: To present a novel digital workflow (the Columbus Digital Bridge Protocol) for immediately loaded full-arch rehabilitations, integrating digital technologies throughout diagnostic, surgical and prosthetic phases, with a focus on the application of intraoral photogrammetry scanning.
Materials And Methods: The workflow presented in this article, successfully implemented in 14 patients, includes standardised clinical steps: digital diagnostic planning through matching of facial scans and CBCT data, surgical placement of four implants following tooth extraction, immediate post-surgical intraoral photogrammetry scanning using a three-step procedure (i.e.
Expert Opin Drug Discov
September 2025
DIFACQUIM Research Group, Department of Pharmacy, School of Chemistry, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Introduction: Cheminformatics has become a cornerstone of modern drug discovery, offering the ability to efficiently manage and analyze large volumes of chemical and biological data. Publicly available databases such as PubChem, ZINC, ChEMBL, DrugBank, ChemDIV, natural product databases, among others, are essential for accessing diverse chemical structures, biological activities, and pharmacological properties.
Areas Covered: This review provides an overview of recent (2024-2025) trends in mining data from PubChem and other representative public databases for virtual screening.
Comput Biol Chem
August 2025
School of Intelligent Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China. Electronic address:
Background: Pulmonary fibrosis is a chronic interstitial lung disease that poses a serious threat to human health. The multi-target actions and favorable safety profile of Traditional Chinese Medicine (TCM) offer new therapeutic possibilities.
Methods: We implemented an integrated strategy combining clinical expertise, computer-aided drug design (CADD), and TCM GuiJing theory for novel formula discovery.
AAPS PharmSciTech
September 2025
Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA.
Pediatric neuropathy poses significant challenges in pain management due to the limited availability of approved pharmacological options. Gabapentin, commonly used for neuropathic pain, offers therapeutic potential but necessitates careful dosing due to its variable bioavailability. This study investigates the integration of Hot Melt Extrusion and Fused Deposition Modeling in the development of polycaprolactone-based implants for sustained release of Gabapentin.
View Article and Find Full Text PDFJ Prosthet Dent
September 2025
Chief, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongq
Statement Of Problem: Immediate implant and interim restoration placement in the maxillary anterior esthetic zone presents challenges in achieving optimal implant positioning, esthetics, and peri-implant tissue stability. A more accurate and efficient clinical workflow is needed to address these demands.
Purpose: This study aimed to establish a fully digital workflow that combines autonomous robotic-assisted immediate implant placement and prefabricated interim restorations in the maxillary anterior esthetic region and to evaluate its accuracy and short-term clinical outcomes.