Exploiting PubChem and other public databases for virtual screening in 2025: what are the latest trends?

Introduction: Cheminformatics has become a cornerstone of modern drug discovery, offering the ability to efficiently manage and analyze large volumes of chemical and biological data. Publicly available databases such as PubChem, ZINC, ChEMBL, DrugBank, ChemDIV, natural product databases, among others, are essential for accessing diverse chemical structures, biological activities, and pharmacological properties.

Areas Covered: This review provides an overview of recent (2024-2025) trends in mining data from PubChem and other representative public databases for virtual screening.