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The increasing demand for healthier food products, with reduced levels of table salt, sugar, and mono sodium glutamate, reinforce the need for novel taste enhancers prepared by means of food-grade kitchen-type chemistry. Although several taste modulating compounds have been discovered in processed foods, their Maillard-type ex food production is usually not exploited by industrial process reactions as the yields of target compounds typically do not exceed 1-2%. Natural deep eutectic solvents (NADES) are reported for the first time to significantly increase the yields of the taste enhancers 1-deoxy-ᴅ-fructosyl-N-β-alanyl-ʟ-histidine (49% yield), N-(1-methyl-4-oxoimidazolidin-2-ylidene) aminopropionic acid (54% yield) and N²-(1-carboxyethyl) guanosine 5'-monophosphate (22% yield) at low temperature (80-100 °C) within a maximum reaction time of 2 h. Therefore, NADES open new avenues to a "next-generation culinary chemistry" overcoming the yield limitations of traditional Maillard chemistry approaches and enable a food-grade Maillard-type generation of flavor modulators.
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http://dx.doi.org/10.3390/molecules23020261 | DOI Listing |
Crit Rev Food Sci Nutr
September 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China.
Natural products have emerged as a vital source of active ingredients in medicine, food, and cosmetics due to their unique biological activities, safety profiles, and sustainability. However, most bioactive compounds in natural products are intensely bitter, limiting their use in pharmaceuticals and foods. The bitter taste attributes vary markedly among different compound classes, predominantly due to their structural characteristics.
View Article and Find Full Text PDFJ Pharm Pharmacol
September 2025
Facultad de Farmacia y Bioquímica, Departamento de Tecnología Farmacéutica, Cátedra de Tecnología Farmacéutica II, Universidad de Buenos Aires, C1113AAD Buenos Aires, Argentina.
Objectives: To develop the orphan drug benznidazole (BNZ) in orally disintegrating tablets, for the neglected disease American Trypanosomiasis (Chagas disease) therapy. Although children are highly affected by this disease, there are no specific commercial pharmaceutical preparations for this age group in Argentina and in many other countries.
Methods: In the production process, co-milling in a ball mill was applied to enhance dissolution rates, followed by direct compression.
Food Res Int
November 2025
Centre for Pre-clinical Studies, Biological Sciences and Technology Division, CSIR-North East Institute of Science and Technology (NEIST), Jorhat, Assam 785006, India; AcSIR-Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh 201002, India. Electronic address:
This is the first report on the functional potential of Akhuni, an ethnic food of Northeast India, against diabetes. Akhuni is a traditional fermented soybean product known for its umami taste and delicacy, commonly used in the cuisine of Northeast India. Treatment with ethanolic extract of Akhuni (AKET) for 8 weeks decreased glucose levels in the blood, increased body mass and enhanced the ability to tolerate glucose dose-dependently in the streptozotocin-induced diabetic mice in comparison with the group of diabetic control mice (DBC).
View Article and Find Full Text PDFFood Res Int
November 2025
Jilin Provincial Key Laboratory of Nutrition and Functional Food, Jilin University, Changchun 130062, People's Republic of China; College of Food Science and Engineering, Jilin University, Changchun 130062, People's Republic of China. Electronic address:
Egg white peptides (EWPs) face significant flavor challenges due to bitterness, limiting their high-value applications. This study prepared egg white glycopeptides (EWGP) through transglutaminase-catalyzed glycosylation to investigate their flavor enhancement effect. Egg white protein was hydrolyzed by neutral protease and covalently bound to glucosamine under the mediation of transglutaminase to obtain EWGP.
View Article and Find Full Text PDFFood Res Int
November 2025
College of Food Science and Engineering, Gansu Agricultural University, Lanzhou, China. Electronic address:
In this study, yak bone collagen peptide-tea polyphenol binding peptides (YCP/TP) were successfully prepared and investigated for their positive effects in replacing nitrite to improve the color, texture, flavor and bacterial community structure of fermented sausages. Results showed that YCP/TP primarily binds through hydrogen bond interactions, enhancing its stability and functional properties. The YCP/TP can effectively inhibit the increase in pH, protein carbonyls and TBARS (p < 0.
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