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Inconsistency scales represent a promising method for separating valid and invalid personality profiles. In a sample of 1,258 participants in the waiting room of the emergency department of an urban university hospital, we examined whether data from participants with profiles flagged as invalid (n = 132) using the Variable Response Inconsistency (VRIN) or True Response Inconsistency (TRIN) scales of the Multidimensional Personality Questionnaire's brief form (MPQ-BF) differed from those that did not exceed any validity cutoffs (n = 1,026). Invalid profiles' scores on many scales were less internally consistent and had less variability than those from valid profiles, especially for random and acquiescent response styles. Scores on MPQ-BF primary trait scales from profiles featuring random responses appeared more psychologically maladjusted than those on valid profiles. Compared to primary trait scores on valid profiles, acquiescent profiles generally had higher scores, and counteracquiescent profiles had lower scores. The higher order component structure of invalid profiles was less consistent with published MPQ-BF component structures than that of valid profiles, though negative emotionality was generally reasonably well-preserved. Scores on primary traits associated with negative emotionality generally had larger correlations with demographic criteria for valid profiles than invalid profiles. These results argue that inconsistency scales meaningfully identify invalid profiles in normal-range personality assessment. (PsycINFO Database Record
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http://dx.doi.org/10.1037/pas0000452 | DOI Listing |
Nutr Rev
September 2025
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Pomegranate (Punica granatum L) is a rich source of bioactive compounds, including punicalagin, ellagic acid, anthocyanins, and urolithins, which contribute to its broad pharmacological potential. This review summarizes evidence from in vitro and in vivo experiments, as well as clinical studies, highlighting pomegranate's therapeutic effects in inflammation, metabolic disorders, cancer, cardiovascular disease, neurodegeneration, microbial infections, and skin conditions. Mechanistic insights show modulation of pathways such as nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK), alpha serine/threonine-protein kinase (AKT1), and nuclear factor erythroid 2-related factor 2 (Nrf2).
View Article and Find Full Text PDFAm J Reprod Immunol
September 2025
Department of Laboratory Animal Science, Kunming Medical University, Kunming, China.
Objective: To explore B cell infiltration-related genes in endometriosis (EM) and investigate their potential as diagnostic biomarkers.
Methods: Gene expression data from the GSE51981 dataset, containing 77 endometriosis and 34 control samples, were analyzed to detect differentially expressed genes (DEGs). The xCell algorithm was applied to estimate the infiltration levels of 64 immune and stromal cell types, focusing on B cells and naive B cells.
PLoS One
September 2025
Department of Neurology, Hospital Universitario Miguel Servet, Zaragoza, Spain.
Background: Stroke is a leading cause of death and disability globally, with frequent cognitive sequelae affecting up to 60% of stroke survivors. Despite the high prevalence of post-stroke cognitive impairment (PSCI), early detection remains underemphasized in clinical practice, with limited focus on broader neuropsychological and affective symptoms. Stroke elevates dementia risk and may act as a trigger for progressive neurodegenerative diseases.
View Article and Find Full Text PDFPLoS One
September 2025
Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Background: Disulfidptosis, a novel cellular death manner, has yet to be fully explored within the context of pulmonary arterial hypertension (PAH). This study aims to identify genes implicated in PAH that are involved in disulfidptosis.
Method: Based on data from the GEO database, this study employed co-expression analysis, Weighted Gene Co-Expression Network Analysis (WGCNA), hub gene identification, and Gene Set Enrichment Analysis (GSEA) to uncover genes associated with PAH and disulfidptosis.
Oncologist
September 2025
Department of Breast Cancer Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China.
Background: THP (trastuzumab + paclitaxel + pertuzumab) and THPy (trastuzumab + paclitaxel + pyrotinib) are widely used as first-line regimens for human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) in China. However, direct comparative data on their efficacy and safety remain scarce. This study evaluates and compares the clinical outcomes of THPy and THP in the first-line treatment of HER2-positive MBC to guide clinical decision-making.
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