Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
To determine the serum prealbumin (PA), retinol binding protein (RBP), and retinol levels in adult patients with type 1 diabetes (T1D) and to analyze some factors related to those levels. A total of 93 patients (47 women) were studied. Age, gender, BMI, duration of diabetes, chronic complications, HbA1c, lipid profile, creatinine, albumin, PA, RBP, and retinol were recorded. High and low parameter groups were compared by Mann-Whitney and tests. Correlation between parameters was analyzed by Spearman's test. Odds of low levels were analyzed by univariate logistic regression and included in the multivariate analysis when significant. 49.5%, 48.4%, and 30.1% of patients displayed serum PA, RBP, and retinol levels below normal values, respectively. A high correlation (Rho > 0.8) between PA, RBP, and retinol serum levels was found. Patients presenting low levels of any of them were predominantly women, normal-weighted, and with lower levels of triglycerides and serum creatinine. No differences in age, macrovascular complications, duration of diabetes, or HbA1c values were observed when comparing low and normal parameter groups. Low serum levels of PA, RBP, and retinol are frequent in T1D adult patients. This alteration is influenced by female sex and serum creatinine and triglyceride levels.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153501 | PMC |
| http://dx.doi.org/10.1155/2016/2532108 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of Plasma Aldosterone Concentration With Early Renal Injury Biomarkers in Primary Aldosteronism: A Propensity-Matched Comparative Study.
J Clin Hypertens (Greenwich)
August 2025
Department of Cardiovascular Medicine, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, China.
Primary aldosteronism (PA) independently increases renal impairment risk beyond blood pressure effects. Although hyperaldosteronism is known to mediate renal injury, associations between plasma aldosterone concentration (PAC) and early kidney damage biomarkers such as retinol-binding protein (RBP) and β2-microglobulin (β2-MG) remain insufficiently explored. We investigated the association of PAC with renal function indicators-including RBP, β2-MG, albumin-to-creatinine ratio (ACR), and estimated glomerular filtration rate (eGFR)-comparing matched patients with PA and essential hypertension (EH).
View Article and Find Full Text PDFA 'Stealth' gene delivery system targeting hepatic stellate cells for the treatment of liver fibrosis.
Int J Pharm
October 2025
NICM Health Research Institute, Western Sydney University, Westmead, Australia. Electronic address:
Liver fibrosis is a progressive condition characterized by excessive accumulation of extracellular matrix components, which impairs liver function and can lead to cirrhosis or hepatocellular carcinoma. In this study, we designed a multifunctional poly(amidoamine) dendrimer-based gene delivery system (VA/CLU/COL-P@mp) to target activated hepatic stellate cells (aHSCs) and mitgate liver fibrosis. This platform leverages clusterin (CLU) for Kupffer cell evasion, collagenase I (COL) to enhance nanoparticle penetration through fibrotic ECM, and vitamin A for targeted binding to retinol-binding protein (RBP) receptors on aHSCs.
View Article and Find Full Text PDFThree Major Deficiency Diseases Harming Mankind (Protein, Retinoid, Iron) Operate Under Tryptophan Dependency.
Nutrients
July 2025
Laboratory of Nutrition, Faculty of Pharmacy, University of Strasbourg, 67401 Strasbourg, France.
This story began half a century ago with the discovery of an unusually high presence of tryptophan (Trp, W) in transthyretin (TTR), one of the three carrier proteins of thyroid hormones. With the Trp-rich retinol-binding protein (RBP), TTR forms a plasma complex implicated in the delivery of retinoid compounds to body tissues. W has the lowest concentration among all AAs involved in the sequencing of human body proteins.
View Article and Find Full Text PDFDynamic changes in nutritional status and sleep disturbance in Parkinson's disease.
Exp Gerontol
October 2025
Department of General Practice, First Hospital of Hebei Medical University, Shijia zhuang, China. Electronic address:
Purpose: This study aims to investigate the relationship between dynamic changes in nutritional status and sleep disturbance in patients with Parkinson's disease (PD).
Methods: This study included 209 PD patients with regular follow-ups from January 2021 to January 2023. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI).
Pancreatic enzyme replacement therapy can improve infection level nutrition condition and prognosis of patients with sepsis.
Food Nutr Res
July 2025
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, P.R. China.
Objective: This study aimed to investigate the effects of pancreatic enzyme replacement therapy (PERT) on infection level, nutrition condition and prognosis of patients with sepsis.
Method: According to the fecal elastase-1 (FE1) level, 68 sepsis patients who were diagnosed with pancreatic exocrine insufficiency (PEI) from 2014.11 to 2015.