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In 2008, we established the Integrated Graduate Program in Physical and Engineering Biology (IGPPEB) at Yale University. Our goal was to create a comprehensive graduate program to train a new generation of scientists who possess a sophisticated understanding of biology and who are capable of applying physical and quantitative methodologies to solve biological problems. Here we describe the framework of the training program, report on its effectiveness, and also share the insights we gained during its development and implementation. The program features co-teaching by faculty with complementary specializations, student peer learning, and novel hands-on courses that facilitate the seamless blending of interdisciplinary research and teaching. It also incorporates enrichment activities to improve communication skills, engage students in science outreach, and foster a cohesive program cohort, all of which promote the development of transferable skills applicable in a variety of careers. The curriculum of the graduate program is integrated with the curricular requirements of several Ph.D.-granting home programs in the physical, engineering, and biological sciences. Moreover, the wide-ranging recruiting activities of the IGPPEB serve to enhance the quality and diversity of students entering graduate school at Yale. We also discuss some of the challenges we encountered in establishing and optimizing the program, and describe the institution-level changes that were catalyzed by the introduction of the new graduate program. The goal of this article is to serve as both an inspiration and as a practical "how to" manual for those who seek to establish similar programs at their own institutions. © 2016 by The International Union of Biochemistry and Molecular Biology, 44(6):537-549, 2016.
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http://dx.doi.org/10.1002/bmb.20977 | DOI Listing |
Eur J Orthop Surg Traumatol
September 2025
Human Anatomy Teaching and Research Section, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.
Objective: Reveal the changing rule of the positional relationship between the uncinate process of cervical spine and vertebral artery by measuring the relevant parameters between the uncinate process of cervical spine and vertebral artery in different age groups.
Methods: A retrospective study was conducted on 1240 cases of cervical spine imaging data from 2018 to 2021 in the Radiology Department of the Affiliated Hospital of Inner Mongolia Medical University. The distance between the uncinate process superior ridge and vertebral artery and the maximum of pedicle transverse angle, the minimum of pedicle transverse angle, the range of pedicle transverse angle and the pedicle width were measured according to age groups.
J Sci Food Agric
September 2025
Graduate School of Horticulture, Chiba University, Matsudo, Japan.
Background: The present study investigated the influence of mild heat treatment on harvested raw rough rice (Oryza sativa L. cv. Toyomeki) by warm water soaking at 65 °C with respect to the physicochemical properties and starch digestibility of cooked rice.
View Article and Find Full Text PDFJ Orthop Res
September 2025
Faulty of Applied Science and Engineering, University of Toronto, Toronto, Canada.
Proper alignment between donor and recipient cartilage in osteochondral allograft transplantation supports tissue integration and the formation of a stable articulating surface. This study evaluated the use of patient-specific 3D-printed drill guides to improve alignment in an ovine model of osteochondral allograft transplantation when used in place of a free-hand drilling technique. Fourteen female Arcott sheep underwent bilateral osteochondral allograft transplantation.
View Article and Find Full Text PDFNutr Clin Pract
September 2025
Nutrition Department, Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Background: Early diagnosis of malnutrition is essential for rapid decision-making regarding nutrition care to improve patient outcomes. We aimed to evaluate the prevalence of malnutrition using the Global Leadership Initiative on Malnutrition (GLIM) criteria and to assess the association of GLIM with 1-year mortality and length of hospital stay (LOS) in patients admitted to an emergency department (ED).
Methods: Prospective cohort study conducted in the ED of a university hospital.
Biophys J
September 2025
Department of Chromosome Science, National Institute of Genetics, Yata 1111, Mishima, 411-8540, Japan; Genetics Program, Sokendai, Yata 1111, Mishima, 411-8540, Japan.
The viscosity of the plasma membrane in living cells is a crucial biophysical parameter that regulates cellular functions. We categorize the plasma membrane viscosity into short-range and long-range viscosities based on the spatial scale of the cellular processes they influence. Short-range viscosity originates from the Brownian motion of membrane molecules, i.
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