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Herein, we report a biocompatible amphiphilic block copolymer micelle bearing a singlet oxygen-sensitive vinyldithioether cleavable linker at the core-shell junction, which undergoes singlet oxygen-mediated photocleavage in the presence of visible light. The micelle facilitates the light-responsive release of singlet oxygen and an anticancer drug for enhanced photodynamic therapy.
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http://dx.doi.org/10.1039/c5cc01937k | DOI Listing |
J Colloid Interface Sci
August 2025
Guangdong Engineering Technology Research Center of Water Treatment Processes and Materials, College of Environment and Climate, Jinan University, Guangzhou 511443, China. Electronic address:
This study systematically investigated the mechanism by which manganese-doped cobalt oxide activates peroxymonosulfate (PMS) for pollutant degradation, with particular emphasis on the formation pathway of singlet oxygen (O), and further assessed the practical applicability of this catalytic system. Doping CoO with Mn effectively optimized the catalyst's surface electronic structure, thereby increasing the Co content and enhancing oxygen vacancy density. The MnCoO/PMS system achieved complete degradation of ciprofloxacin (CIP) within 5 min.
View Article and Find Full Text PDFAnal Chem
September 2025
School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Traditional lipidomics methods are not well-suited for studying unsaturated lipids containing located C═C bonds in single cells. Here, we proposed a single-cell mass spectrometry (MS) platform assisted by a photochemical derivatization (PCD) method termed isible-light-activated u(bpy)-catalyzed inglet xygen-mediated ydroperoxidation (VRSOH), for the rapid and simultaneous detection of multiple lipid C═C location isomers in living cell membranes at the single-cell level. First, the VRSOH method combined with MS analysis achieved the localization of C═C bonds in mono- and polyunsaturated lipids and cellular lipid extracts.
View Article and Find Full Text PDFResearch (Wash D C)
August 2025
State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Afterglow imaging offers exceptional signal-to-background ratios (SBRs) by circumventing real-time excitation and autofluorescence, yet conventional systems rely on visible-light excitation, limiting tissue penetration and signal intensity. Here, we report near-infrared-excitable organic afterglow nanoparticles (NOANPs) that leverage singlet oxygen (O)-mediated energy transfer to achieve prolonged, high-intensity emission with minimal photobleaching. The nanoparticles integrate a near-infrared-photoactive sensitizer (NAM-0), which generates abundant O under 808-nm laser excitation, and a triplenet-anthracene derivative (TD) as the afterglow substrate, which converts O into sustained luminescence.
View Article and Find Full Text PDFACS Omega
July 2025
State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering, School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, P.R. China.
Cobalt-based heterogeneous catalysts have emerged as high-performance activators of peroxymonosulfate (PMS) for advanced oxidation processes targeting pharmaceutical contaminants. This work presents a morphology-engineered spinelloid phase (g-CoMnO) synthesized through a glycerol-modulated crystallization strategy, exhibiting a 3D hierarchical nanofloral architecture with enhanced interfacial active sites. Remarkable tetracycline (TC) degradation efficiency of 98.
View Article and Find Full Text PDFDalton Trans
July 2025
Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh 221005, India.
In this work, four novel Fe(III) complexes , [Fe(dpa)(L1)]Cl (Fe1), [Fe(Fc-dpa)(L1)]Cl (Fe2), [Fe(dpa)(L2)]Cl (Fe3), and [Fe(Fc-dpa)(L2)]Cl (Fe4), where dpa = bis(2-pyridylmethyl)amine; Fc-dpa = -(1-ferrocenyl)-methyl-1-(pyridine-2-yl)--(pyridine-2-ylmethyl)methanamine; HL = ()-2(2-hydroxybenzylidene)amino)phenol and HL = ()-1-(2-hydroxyphenyl)imino)methyl)naphthalen-2-ol, have been synthesized and characterized. The light-responsive nature of these complexes was tailored by extending π conjugation or attaching a ferrocene moiety in the ligands. These complexes displayed light absorption within the visible region with ∼ 450 nm.
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